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cyb5r1 cytochrome b5 reductase 1 [ Danio rerio (zebrafish) ]

Gene ID: 336553, updated on 27-Mar-2024

Summary

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Official Symbol
cyb5r1provided by ZNC
Official Full Name
cytochrome b5 reductase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8497
See related
Ensembl:ENSDARG00000018966 AllianceGenome:ZFIN:ZDB-GENE-030131-8497
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dia1; zgc:56042; wu:fb13e02; wu:fb15h03
Summary
Predicted to enable FAD binding activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human CYB5R1 (cytochrome b5 reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (24786418..24799675)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (24548802..24562059)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene innate immunity activator b Neighboring gene arginyl aminopeptidase (aminopeptidase B) Neighboring gene adiponectin receptor 1a Neighboring gene RAB interacting factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of the proteins required for fatty acid desaturation in zebrafish (Danio rerio). Chen YS, et al. Biochem Biophys Res Commun, 2013 Nov 1. PMID 24103751
  2. Adiponectin and adiponectin receptor genes are coexpressed during zebrafish embryogenesis and regulated by food deprivation. Nishio S, et al. Dev Dyn, 2008 Jun. PMID 18489000
  3. Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio). van der Meulen T, et al. Am J Physiol Regul Integr Comp Physiol, 2006 Oct. PMID 16966387
  4. Effects of decreased muscle activity on developing axial musculature in nicb107 mutant zebrafish (Danio rerio). van der Meulen T, et al. J Exp Biol, 2005 Oct. PMID 16169945
  5. Early depletion of primordial germ cells in zebrafish promotes testis formation. Tzung KW, et al. Stem Cell Reports, 2015 Jan 13. PMID 25434820, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC56042

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADH-cytochrome b5 reductase 1
Names
diaphorase (NADH) (cytochrome b-5 reductase)
NP_956483.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200189.2 → NP_956483.1  NADH-cytochrome b5 reductase 1

    See identical proteins and their annotated locations for NP_956483.1

    Status: PROVISIONAL

    Source sequence(s)
    AY398332
    UniProtKB/TrEMBL
    Q7ZVF8
    Related
    ENSDARP00000003519.5, ENSDART00000015374.6
    Conserved Domains (2) summary
    cd06183
    Location:48 → 304
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    PTZ00319
    Location:26 → 304
    PTZ00319; NADH-cytochrome B5 reductase; Provisional

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    24786418..24799675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394820.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    281500..294757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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