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ptgdsb.1 prostaglandin D2 synthase b, tandem duplicate 1 [ Danio rerio (zebrafish) ]

Gene ID: 336492, updated on 27-Mar-2024

Summary

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Official Symbol
ptgdsb.1provided by ZNC
Official Full Name
prostaglandin D2 synthase b, tandem duplicate 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8436
See related
Ensembl:ENSDARG00000027088 AllianceGenome:ZFIN:ZDB-GENE-030131-8436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ptgds; ptgdsb; hm:zeh0800; wu:fb10b10; wu:fb11h03
Summary
Enables retinoic acid binding activity. Predicted to be located in extracellular region. Is expressed in eye; female organism; male organism; postcranial axial skeleton; and reproductive system. Human ortholog(s) of this gene implicated in carotid artery disease; intrahepatic cholangiocarcinoma; and urinary tract infection. Orthologous to several human genes including PTGDS (prostaglandin D2 synthase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 24
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (17027313..17029335, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (16882894..16884916, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2, subunit 3 gamma Neighboring gene zinc finger protein X-linked Neighboring gene prostaglandin D2 synthase b, tandem duplicate 2 Neighboring gene complement component 8, gamma polypeptide Neighboring gene methionine sulfoxide reductase B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of prostaglandin synthases (pgds and pges) during zebrafish gonadal differentiation. Jørgensen A, et al. Comp Biochem Physiol A Mol Integr Physiol, 2010 Sep. PMID 20362066
  2. Zebrafish and chicken lipocalin-type prostaglandin D synthase homologues: Conservation of mammalian gene structure and binding ability for lipophilic molecules, and difference in expression profile and enzyme activity. Fujimori K, et al. Gene, 2006 Jun 21. PMID 16616995
  3. Profiling of prostanoids in zebrafish embryonic development. Yeh HC, et al. Prostaglandins Leukot Essent Fatty Acids, 2006 Dec. PMID 17000094
  4. Limited sex-biased neural gene expression patterns across strains in Zebrafish (Danio rerio). Wong RY, et al. BMC Genomics, 2014 Oct 17. PMID 25326170, Free PMC Article
  5. Molecular effects of the cyanobacterial toxin cyanopeptolin (CP1020) occurring in algal blooms: global transcriptome analysis in zebrafish embryos. Faltermann S, et al. Aquat Toxicol, 2014 Apr. PMID 24561424

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
NOT enables prostaglandin-D synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables prostaglandin-D synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables retinoic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small molecule binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prostaglandin D2 synthase b, tandem duplicate 1
Names
L-PGDS
NP_998799.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213634.1 → NP_998799.1  prostaglandin D2 synthase b, tandem duplicate 1 precursor

    See identical proteins and their annotated locations for NP_998799.1

    Status: PROVISIONAL

    Source sequence(s)
    AB071601
    UniProtKB/TrEMBL
    B2GR30, Q8QGV5
    Related
    ENSDARP00000037484.6, ENSDART00000039267.7
    Conserved Domains (1) summary
    pfam00061
    Location:35 → 176
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    17027313..17029335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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