sod2 superoxide dismutase 2, mitochondrial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sod2provided by ZNC
Official Full Name: superoxide dismutase 2, mitochondrialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7742
See related: Ensembl:ENSDARG00000042644 AllianceGenome:ZFIN:ZDB-GENE-030131-7742
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb463; zgc:73051; wu:fj33b01
Summary: Enables superoxide dismutase activity. Acts upstream of or within several processes, including neutrophil homeostasis; removal of superoxide radicals; and response to methylmercury. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; hematopoietic cell; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (30939178..30947547)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (31036299..31044668)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within removal of superoxide radicals	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to methylmercury	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within superoxide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: superoxide dismutase [Mn], mitochondrial

Names: Mn-SOD; manganese superoxide dismutase; sod(Mn)

NP_956270.1

EC 1.15.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199976.1 → NP_956270.1 superoxide dismutase [Mn], mitochondrial

See identical proteins and their annotated locations for NP_956270.1

Status: PROVISIONAL

Source sequence(s)

BC060895

UniProtKB/TrEMBL

A0A8M1PC95, Q6P980

Related

ENSDARP00000062555.3, ENSDART00000062556.4

Conserved Domains (3) summary

COG0605
Location:25 → 224

SodA; Superoxide dismutase [Inorganic ion transport and metabolism]

pfam00081
Location:27 → 108

Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain

pfam02777
Location:115 → 218

Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain