U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ptpn6 protein tyrosine phosphatase non-receptor type 6 [ Danio rerio (zebrafish) ]

Gene ID: 335573, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ptpn6provided by ZNC
Official Full Name
protein tyrosine phosphatase non-receptor type 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7513
See related
Ensembl:ENSDARG00000089043 AllianceGenome:ZFIN:ZDB-GENE-030131-7513
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Hcph; SHP1; fj22f05; zgc:55501; wu:fj22f05
Summary
Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within innate immune response. Predicted to be located in cytoplasm. Is expressed in blood island; gill; immune system; and liver. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 16
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (31720071..31757341, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (31765417..31801756, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily member 5-like Neighboring gene retinol binding protein 1a, cellular Neighboring gene chromodomain helicase DNA binding protein 4b Neighboring gene wingless-type MMTV integration site family, member 4b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae. Allers M, et al. Dis Model Mech, 2023 Feb 1. PMID 36645087, Free PMC Article
  2. Cell surface expression of channel catfish leukocyte immune-type receptors (IpLITRs) and recruitment of both Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 and SHP-2. Montgomery BC, et al. Dev Comp Immunol, 2009 Apr. PMID 19013191
  3. Early Life Glucocorticoid Exposure Modulates Immune Function in Zebrafish (Danio rerio) Larvae. van den Bos R, et al. Front Immunol, 2020. PMID 32411141, Free PMC Article
  4. Inhibition of the Pim1 oncogene results in diminished visual function. Yin J, et al. PLoS One, 2012. PMID 23300608, Free PMC Article
  5. Macrophage-specific gene functions in Spi1-directed innate immunity. Zakrzewska A, et al. Blood, 2010 Jul 22. PMID 20424185

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae.
    Title: Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae.
  2. we present a new hyperinsulinemia animal model and propose ptpn6 as a key mediator triggering hyperinsulinemia-derived insulin resistance and immune suppression.
    Title: Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.
  3. ptpn6 knockdown induces a spontaneous inflammation-associated phenotype at the late larval stage.
    Title: Deficiency in hematopoietic phosphatase ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to organic substance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of macrophage migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of neutrophil differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of neutrophil migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tyrosine-protein phosphatase non-receptor type 6
NP_956254.1
XP_009290703.1
XP_009290704.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199960.1 → NP_956254.1  tyrosine-protein phosphatase non-receptor type 6

    See identical proteins and their annotated locations for NP_956254.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044414
    UniProtKB/TrEMBL
    Q803M6
    Related
    ENSDARP00000105983.2, ENSDART00000126617.4
    Conserved Domains (4) summary
    cd09931
    Location:109 → 212
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:3 → 101
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:246 → 517
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:276 → 517
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    31720071..31757341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292429.3 → XP_009290704.1  tyrosine-protein phosphatase non-receptor type 6 isoform X2

    See identical proteins and their annotated locations for XP_009290704.1

    UniProtKB/TrEMBL
    A0A8N7XJL7, E7F3D4, S6CNK8
    Conserved Domains (4) summary
    cd09931
    Location:109 → 212
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:3 → 101
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:246 → 517
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:276 → 517
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. XM_009292428.2 → XP_009290703.1  tyrosine-protein phosphatase non-receptor type 6 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Q2T0, A0A8M3AJ85
    Related
    ENSDARP00000148161.1, ENSDART00000185043.1
    Conserved Domains (4) summary
    cd09931
    Location:110 → 213
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:4 → 102
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:247 → 518
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:277 → 518
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394963.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    1278..21739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.