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Spf45 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355114, updated on 10-May-2024

Summary

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Official Symbol
Spf45provided by FlyBase
Primary source
FLYBASE:FBgn0086683
Locus tag
Dmel_CG17540
See related
AllianceGenome:FB:FBgn0086683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17540; Dmel\CG17540; dRBM17; dSPF45; RBM17; spf-45; spf45; SPF45
Summary
Predicted to enable nucleic acid binding activity. Involved in DNA repair; compound eye morphogenesis; and regulation of alternative mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in organism. Orthologous to human RBM17 (RNA binding motif protein 17). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
40F7-40F7; 2-54 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (23066874..23068386, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22959606..22961118, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene concertina Neighboring gene Chitinase 10 Neighboring gene long non-coding RNA:CR43242 Neighboring gene uncharacterized protein Neighboring gene mir-2490 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45. Lallena MJ, et al. Cell, 2002 May 3. PMID 12015979
  2. U2AF homology motifs: protein recognition in the RRM world. Kielkopf CL, et al. Genes Dev, 2004 Jul 1. PMID 15231733, Free PMC Article
  3. Sex, AGility, and the regulation of alternative splicing. Graveley BR. Cell, 2002 May 17. PMID 12086596
  4. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Lim J, et al. Nature, 2008 Apr 10. PMID 18337722, Free PMC Article
  5. Drosophila SPF45: a bifunctional protein with roles in both splicing and DNA repair. Chaouki AS, et al. PLoS Genet, 2006 Dec 8. PMID 17154718, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in compound eye morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
Spf45
Names
CG17540-PA
CG17540-PB
CG17540-PC
RNA binding motif protein 1
Spf45-PA
Spf45-PB
Spf45-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    23066874..23068386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042960.3 → NP_001036425.1  Spf45, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036425.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7PL81, Q8SYI1
    Conserved Domains (2) summary
    cd12647
    Location:275 → 370
    RRM_UHM_SPF45; RNA recognition motif in UHM domain of 45 kDa-splicing factor (SPF45) and similar proteins
    pfam01585
    Location:177 → 216
    G-patch; G-patch domain

  2. NM_001042961.3 → NP_001036426.1  Spf45, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036426.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7PL83, Q8SYI1
    Conserved Domains (2) summary
    cd12647
    Location:307 → 402
    RRM_UHM_SPF45; RNA recognition motif in UHM domain of 45 kDa-splicing factor (SPF45) and similar proteins
    pfam01585
    Location:209 → 248
    G-patch; G-patch domain

  3. NM_001042959.3 → NP_001036424.1  Spf45, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036424.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL39, Q7PL82
    Conserved Domains (2) summary
    cd12647
    Location:267 → 362
    RRM_UHM_SPF45; RNA recognition motif in UHM domain of 45 kDa-splicing factor (SPF45) and similar proteins
    pfam01585
    Location:169 → 208
    G-patch; G-patch domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7PL81 Q7PL81
Q7PL82 Q7PL82
Q7PL83 Q7PL83
Q8SYI1 Q8SYI1

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