U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

eIF4B eukaryotic translation initiation factor 4B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355041, updated on 29-Dec-2023

Summary

Go to the top of the page Help
Official Symbol
eIF4Bprovided by FlyBase
Official Full Name
eukaryotic translation initiation factor 4Bprovided by FlyBase
Primary source
FLYBASE:FBgn0020660
Locus tag
Dmel_CG10837
See related
AllianceGenome:FB:FBgn0020660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10837; Dm-eIF4B; Dmel\CG10837; eIF-4b; eIF-4B; EIF-4B; eIF-4B-L; eIF-4B-S; eIf4b; Eif4B; EIF4B; eIF4B-L; eIF4B-S
Summary
Enables translation initiation factor activity. Involved in translational initiation. Located in cytosol. Is expressed in adult brain cell body rind; adult head; and organism. Orthologous to human EIF4B (eukaryotic translation initiation factor 4B). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
80F9-80F9; 3-47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (27842669..27858271, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (2901758..2917360)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein L15 Neighboring gene long non-coding RNA:CR46250 Neighboring gene Dead box protein 80 Neighboring gene long non-coding RNA:CR46482 Neighboring gene pseudo Neighboring gene lethal (3) 80Fj

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence. McGurk L, et al. Hum Mol Genet, 2021 Sep 15. PMID 34077532, Free PMC Article
  2. Heat shock effects on phosphorylation of protein synthesis initiation factor proteins eIF-4E and eIF-2 alpha in Drosophila. Duncan RF, et al. Biochemistry, 1995 Mar 7. PMID 7893711
  3. TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction. Penney J, et al. Neuron, 2012 Apr 12. PMID 22500638
  4. Two functionally redundant isoforms of Drosophila melanogaster eukaryotic initiation factor 4B are involved in cap-dependent translation, cell survival, and proliferation. Hernández G, et al. Eur J Biochem, 2004 Jul. PMID 15233788
  5. The insulin receptor cellular IRES confers resistance to eIF4A inhibition. Olson CM, et al. Elife, 2013 Jul 16. PMID 23878722, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that two functionally redundant isoforms of Drosophila eukaryotic initiation factor 4B are involved in cap-dependent translation, cell survival, and proliferation.
    Title: Two functionally redundant isoforms of Drosophila melanogaster eukaryotic initiation factor 4B are involved in cap-dependent translation, cell survival, and proliferation.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in translational initiation IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
eukaryotic translation initiation factor 4B
Names
CG10837-PA
CG10837-PB
CG10837-PE
CG10837-PF
eIF4B-PA
eIF4B-PB
eIF4B-PE
eIF4B-PF
eukaryotic initiation factor 4B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    27842669..27858271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276232.1 → NP_001263161.1  eukaryotic translation initiation factor 4B, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L7EEF1
    Conserved Domains (2) summary
    COG0724
    Location:72 → 268
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12402
    Location:79 → 155
    RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

  2. NM_001015319.2 → NP_001015319.1  eukaryotic translation initiation factor 4B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015319.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7PLL3
    Conserved Domains (2) summary
    COG0724
    Location:72 → 268
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12402
    Location:79 → 155
    RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

  3. NM_001015320.2 → NP_001015320.1  eukaryotic translation initiation factor 4B, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015320.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7PLL1
    Conserved Domains (2) summary
    COG0724
    Location:72 → 268
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12402
    Location:79 → 155
    RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

  4. NM_001015321.2 → NP_001015321.1  eukaryotic translation initiation factor 4B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015321.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYL3
    Conserved Domains (2) summary
    COG0724
    Location:72 → 268
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12402
    Location:79 → 155
    RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
L7EEF1 L7EEF1
Q7PLL1 Q7PLL1
Q7PLL3 Q7PLL3
Q8SYL3 Q8SYL3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous