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su(f) suppressor of forked [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3354994, updated on 10-May-2024

Summary

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Official Symbol
su(f)provided by FlyBase
Official Full Name
suppressor of forkedprovided by FlyBase
Primary source
FLYBASE:FBgn0003559
Locus tag
Dmel_CG17170
See related
AllianceGenome:FB:FBgn0003559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
19; 28; 29; 3-DES; 3DES; CG17170; CstF-77; Cstf77; CstF77; Dmel\CG17170; EC235; l(1)20Eb; l(1)3DES; l(1)EC235; l(1)G0393; l(1)R-9-18; l(1)su(f); l(1)X1; l(1)X3; l3DES; R-9-18; R9-18; Su(f); su-f; SU-f; su[+]-f
Summary
Predicted to enable mRNA binding activity. Involved in positive regulation of malate dehydrogenase (decarboxylating) (NADP+) activity. Part of mRNA cleavage stimulating factor complex. Is expressed in adult head; eye disc anterior to the morphogenetic furrow; imaginal disc; and organism. Orthologous to human CSTF3 (cleavage stimulation factor subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
20F4-20F4; 1-66 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (23096771..23101431)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) XHet NW_001848859.1 (75589..80249)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43480 Neighboring gene pseudo Neighboring gene (A+T)-stretch binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ecdysterone responsive functions in the mutantl(1)su(f) (ts67g) ofDrosophila melanogaster. Hansson L, et al. Wilehm Roux Arch Dev Biol, 1984 Jan. PMID 28305496
  2. Pattern specification in imaginal discs ofDrosophila melanogaster : Developmental analysis of a temperature-sensitive mutant producing duplicated legs. Jürgens G, et al. Wilehm Roux Arch Dev Biol, 1979 Mar. PMID 28305309
  3. Effect of the l(1)su(f)(ts67g) mutation ofDrosophila melanogaster on glue protein synthesis. Hansson L, et al. Wilehm Roux Arch Dev Biol, 1981 Nov. PMID 28305289
  4. Pattern formation in a ts-cell-lethal mutant ofDrosophila: The range of phenotypes induced by larval heat treatments. Russell MA, et al. Wilehm Roux Arch Dev Biol, 1977 Mar. PMID 28305113
  5. Development of cuticular patterns in the legs of a cell lethal mutant ofDrosophila melanogaster. Postlethwait JH. Wilehm Roux Arch Dev Biol, 1978 Mar. PMID 28304860

See all (174) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. su(f) is required for the cleavage of pre-mRNA during mRNA 3' end formation
    Title: Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage stimulating factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
suppressor of forked
Names
CG17170-PE
CG17170-PF
CG17170-PG
lethal3Des
section 19
section 28
section 29
su(f)-PE
su(f)-PF
su(f)-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    23096771..23101431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001111010.3 → NP_001104480.2  suppressor of forked, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001104480.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25991
    Conserved Domains (3) summary
    smart00386
    Location:48 → 78
    HAT; HAT (Half-A-TPR) repeats
    COG0457
    Location:245 → 519
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    pfam05843
    Location:376 → 650
    Suf; Suppressor of forked protein (Suf)

  2. NM_001015241.4 → NP_001015241.3  suppressor of forked, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015241.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A023GQK0, A8Y5B4, A8Y5B5, P25991, Q24539, Q5BI40, Q6NKM3, Q7PLW9, Q7PLX0, Q7PLX1, Q8MZI2, Q9W5P7
    Conserved Domains (3) summary
    smart00386
    Location:48 → 78
    HAT; HAT (Half-A-TPR) repeats
    COG5107
    Location:19 → 550
    RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
    pfam05843
    Location:408 → 682
    Suf; Suppressor of forked protein (Suf)

  3. NM_001111009.4 → NP_001104479.1  suppressor of forked, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001104479.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25991
    Conserved Domains (3) summary
    smart00386
    Location:48 → 78
    HAT; HAT (Half-A-TPR) repeats
    COG0457
    Location:245 → 519
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    pfam05843
    Location:376 → 650
    Suf; Suppressor of forked protein (Suf)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25991.2 P25991

Gene LinkOut

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