mpeg1.1 macrophage expressed 1, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mpeg1.1provided by ZNC
Official Full Name: macrophage expressed 1, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7347
See related: Ensembl:ENSDARG00000055290 AllianceGenome:ZFIN:ZDB-GENE-030131-7347
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mpeg1; fj09e08; zgc:66409; wu:fb14d06; wu:fj09e08
Summary: Acts upstream of or within defense response to bacterium. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be integral component of membrane. Is expressed in blood island; digestive system; immune system; reproductive system; and trunk. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MPEG1 (macrophage expressed 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (29710121..29713621, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (29700889..29704389, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ablation of mpeg+ Macrophages Exacerbates mfrp-Related Hyperopia.
Title: Ablation of mpeg+ Macrophages Exacerbates mfrp-Related Hyperopia.
A Population of Injury-Responsive Lymphoid Cells Expresses mpeg1.1 in the Adult Zebrafish Heart.
Title: A Population of Injury-Responsive Lymphoid Cells Expresses mpeg1.1 in the Adult Zebrafish Heart.
Regeneration associated transcriptional signature of retinal microglia and macrophages.
Title: Regeneration associated transcriptional signature of retinal microglia and macrophages.
The macrophage-expressed gene (mpeg) 1 identifies a subpopulation of B cells in the adult zebrafish.
Title: The macrophage-expressed gene (mpeg) 1 identifies a subpopulation of B cells in the adult zebrafish.
mpeg1-driven transgenes are expressed in macrophage-lineage cells that do not express neutrophil-marking transgenes.
Title: mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish.

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General gene information

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Markers

fj09e08.y1 (e-PCR)
- UniSTS:198488

fb14d06.x1 (e-PCR)
- UniSTS:202923

AW184143 (e-PCR)
- UniSTS:205761

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: macrophage expressed 1, tandem duplicate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.