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itgb4 integrin, beta 4 [ Danio rerio (zebrafish) ]

Gene ID: 335269, updated on 11-Apr-2024

Summary

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Official Symbol
itgb4provided by ZNC
Official Full Name
integrin, beta 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7209
See related
Ensembl:ENSDARG00000028507 AllianceGenome:ZFIN:ZDB-GENE-030131-7209
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fl03d06; wu:fb72e01; wu:fc27g01; wu:fl03d06; zgc:136313
Summary
Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within several processes, including cell adhesion; cell motility; and hemidesmosome assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin complex. Predicted to be active in cell surface and focal adhesion. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa non-Herlitz type and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (integrin subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
43
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (13102666..13159584)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (13064979..13121879)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911475 Neighboring gene sperm associated antigen 17 Neighboring gene SAP30 binding protein Neighboring gene zgc:194990 Neighboring gene si:ch73-61d6.3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutation of smooth muscle myosin causes epithelial invasion and cystic expansion of the zebrafish intestine. Wallace KN, et al. Dev Cell, 2005 May. PMID 15866162
  2. Nongenomic effects and mechanistic study of butyl benzyl phthalate-induced thyroid disruption: Based on integrated in vitro, in silico assays and proteome analysis. Li J, et al. Sci Total Environ, 2022 Aug 25. PMID 35525365
  3. Nlcam modulates midline convergence during anterior neural plate morphogenesis. Brown KE, et al. Dev Biol, 2010 Mar 1. PMID 20005219
  4. Zebrafish: a model system to study heritable skin diseases. Li Q, et al. J Invest Dermatol, 2011 Mar. PMID 21191402, Free PMC Article
  5. Expression profiling and comparative genomics identify a conserved regulatory region controlling midline expression in the zebrafish embryo. Dickmeis T, et al. Genome Res, 2004 Feb. PMID 14718378, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC136313

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular component organization IEA
Inferred from Electronic Annotation
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrin beta-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024386.1 → NP_001019557.1  integrin beta-4 precursor

    See identical proteins and their annotated locations for NP_001019557.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ022377
    UniProtKB/TrEMBL
    Q4U0S1
    Related
    ENSDARP00000031533.6, ENSDART00000029308.8
    Conserved Domains (6) summary
    cd00063
    Location:1331 → 1420
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:1713 → 1797
    fn3; Fibronectin type III domain
    pfam00362
    Location:37 → 457
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:625 → 709
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:545 → 573
    EGF_2; EGF-like domain
    cl02522
    Location:991 → 1064
    Calx-beta; Calx-beta domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    13102666..13159584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166791.4 → XP_005166848.1  integrin beta-4 isoform X1

    See identical proteins and their annotated locations for XP_005166848.1

    UniProtKB/TrEMBL
    A0A8M2BEB1
    Conserved Domains (6) summary
    cd00063
    Location:1331 → 1420
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:1751 → 1835
    fn3; Fibronectin type III domain
    pfam00362
    Location:37 → 457
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:625 → 709
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:545 → 573
    EGF_2; EGF-like domain
    cl02522
    Location:991 → 1064
    Calx-beta; Calx-beta domain

  2. XM_005166790.4 → XP_005166847.1  integrin beta-4 isoform X1

    See identical proteins and their annotated locations for XP_005166847.1

    UniProtKB/TrEMBL
    A0A8M2BEB1
    Conserved Domains (6) summary
    cd00063
    Location:1331 → 1420
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:1751 → 1835
    fn3; Fibronectin type III domain
    pfam00362
    Location:37 → 457
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:625 → 709
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:545 → 573
    EGF_2; EGF-like domain
    cl02522
    Location:991 → 1064
    Calx-beta; Calx-beta domain
Nucleotide Protein
Heading Accession and Version

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