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FASN1 Fatty acid synthase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33524, updated on 26-Apr-2024

Summary

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Official Symbol
FASN1provided by FlyBase
Official Full Name
Fatty acid synthase 1provided by FlyBase
Primary source
FLYBASE:FBgn0283427
Locus tag
Dmel_CG3523
See related
AllianceGenome:FB:FBgn0283427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey235; anon-EST:Posey43; anon-WO0138581.1; BcDNA:gh07626; BcDNA:GH07626; CG3523; dFAS; dFASN; dFASN1; Dmel\CG3523; DM_7295848; fas; Fas; FAS; FAS1; fasn; Fasn; FASN; Fasn1; FASN[CG3523]; FAS[CG3523]; Fatty acid synthase
Summary
Enables fatty acid synthase activity and serine hydrolase activity. Involved in several processes, including cellular response to sucrose stimulus; cellular triglyceride homeostasis; and triglyceride biosynthetic process. Acts upstream of with a positive effect on regulation of lipid storage. Is expressed in adult fat body; adult head; adult heart; and embryonic/larval fat body. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
23C5-23D1; 2-8 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3056598..3068177)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3056598..3068177)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene small nuclear RNA U5 at 23D Neighboring gene small nuclear RNA Like U Neighboring gene Fatty acid synthase 2 Neighboring gene toucan Neighboring gene Protein phosphatase D6 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Immuno-electron microscopy of primary cell cultures from genetically modified animals in liquid by atmospheric scanning electron microscopy. Kinoshita T, et al. Microsc Microanal, 2014 Apr. PMID 24564988
  2. Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes. Moraru A, et al. Cell Metab, 2018 Apr 3. PMID 29551588
  3. Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP. Ziegler AB, et al. Cell Rep, 2017 Dec 19. PMID 29262315
  4. A single gene affects both ecological divergence and mate choice in Drosophila. Chung H, et al. Science, 2014 Mar 7. PMID 24526311
  5. Cell cycle regulation of microtubule interactomes: multi-layered regulation is critical for the interphase/mitosis transition. Syred HM, et al. Mol Cell Proteomics, 2013 Nov. PMID 23893837, Free PMC Article

See all (163) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables [acyl-carrier-protein] S-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
  
enables serine hydrolase activity HDA PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to sucrose stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_positive_effect regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to sucrose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
fatty acid synthase 1
Names
CG3523-PA
CG3523-PC
FASN1-PA
FASN1-PC
fatty acid synthase
fatty acid synthetase
NP_001137778.2
NP_608748.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3056598..3068177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134904.3 → NP_608748.1  fatty acid synthase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608748.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQL7, Q9Y129
    Related
    FBpp0077343
    Conserved Domains (11) summary
    cd05195
    Location:1493 → 1781
    enoyl_red; enoyl reductase of polyketide synthase
    cd08954
    Location:1799 → 2039
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:2052 → 2104
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:1491 → 1781
    PKS_ER; Enoylreductase
    COG3321
    Location:35 → 1040
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    cd00833
    Location:38 → 442
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam16197
    Location:400 → 510
    KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
    cl00509
    Location:888 → 1132
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
    cl08282
    Location:531 → 848
    Acyl_transf_1; Acyl transferase domain
    cl21454
    Location:1256 → 1448
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    cl21494
    Location:2184 → 2433
    Abhydrolase; alpha/beta hydrolases

  2. NM_001144306.2 → NP_001137778.2  fatty acid synthase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137778.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z001
    Conserved Domains (11) summary
    cd05195
    Location:1595 → 1883
    enoyl_red; enoyl reductase of polyketide synthase
    cd08954
    Location:1901 → 2141
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:2154 → 2206
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:1593 → 1883
    PKS_ER; Enoylreductase
    COG3321
    Location:137 → 1142
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    cd00833
    Location:140 → 544
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam16197
    Location:502 → 612
    KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
    cl00509
    Location:990 → 1234
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
    cl08282
    Location:633 → 950
    Acyl_transf_1; Acyl transferase domain
    cl21454
    Location:1358 → 1550
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    cl21494
    Location:2286 → 2535
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z001 B7Z001
Q7KML1 Q7KML1
Q9VQL7 Q9VQL7

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