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Sf3b2 Splicing factor 3b subunit 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33514, updated on 10-May-2024

Summary

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Official Symbol
Sf3b2provided by FlyBase
Official Full Name
Splicing factor 3b subunit 2provided by FlyBase
Primary source
FLYBASE:FBgn0031493
Locus tag
Dmel_CG3605
See related
AllianceGenome:FB:FBgn0031493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3605; Dmel\CG3605; SF3B2
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including embryonic ganglion mother cell; embryonic/larval nervous system; endoderm anlage; extended germ band embryo; and germ layer. Orthologous to human SF3B2 (splicing factor 3b subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
23C4-23C4; 2-8 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3026252..3029168, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3026252..3029168, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene alpha1,4-galactosyltransferase 1 Neighboring gene pre-mRNA processing factor 40 Neighboring gene antisense RNA:CR44147 Neighboring gene uncharacterized protein Neighboring gene beta4GalNAcTB pilot Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Agaisse H, et al. Science, 2005 Aug 19. PMID 16020693
  2. Conserved functions of RNA-binding proteins in muscle. Nikonova E, et al. Int J Biochem Cell Biol, 2019 May. PMID 30818081
  3. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
  4. The Exon Junction Complex and Srp54 Contribute to Hedgehog Signaling via ci RNA Splicing in Drosophila melanogaster. Garcia-Garcia E, et al. Genetics, 2017 Aug. PMID 28637711, Free PMC Article
  5. Computational identification of Ftz/Ftz-F1 downstream target genes. Bowler T, et al. Dev Biol, 2006 Nov 1. PMID 16996052

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of U2-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome HDA PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of precatalytic spliceosome HDA PubMed 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
splicing factor 3b subunit 2
Names
CG3605-PA
CG3605-PB
Sf3b2-PA
Sf3b2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3026252..3029168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273050.1 → NP_001259979.1  splicing factor 3b subunit 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259979.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RC1, Q9VQK7
    Conserved Domains (3) summary
    smart00581
    Location:451 → 508
    PSP; proline-rich domain in spliceosome associated proteins
    COG5182
    Location:166 → 536
    CUS1; Splicing factor 3b, subunit 2 [RNA processing and modification]
    pfam04037
    Location:320 → 446
    DUF382; Domain of unknown function (DUF382)

  2. NM_134895.4 → NP_608739.1  splicing factor 3b subunit 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608739.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RC1, Q9VQK7
    Related
    FBpp0077353
    Conserved Domains (3) summary
    smart00581
    Location:451 → 508
    PSP; proline-rich domain in spliceosome associated proteins
    COG5182
    Location:166 → 536
    CUS1; Splicing factor 3b, subunit 2 [RNA processing and modification]
    pfam04037
    Location:320 → 446
    DUF382; Domain of unknown function (DUF382)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQK7 Q9VQK7

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