ptprub protein tyrosine phosphatase receptor type Ub [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptprubprovided by ZNC
Official Full Name: protein tyrosine phosphatase receptor type Ubprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7036
See related: Ensembl:ENSDARG00000101081 AllianceGenome:ZFIN:ZDB-GENE-030131-7036
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ptpru; R-PTP-U; fj42a04; fk66g06; RPTP-psi; R-PTP-psi; wu:fj42a04; wu:fk66g06; zmp:0000001038
Summary: Predicted to enable transmembrane receptor protein tyrosine phosphatase activity. Acts upstream of or within somite specification. Predicted to be integral component of membrane. Orthologous to human PTPRU (protein tyrosine phosphatase receptor type U). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (34913281..35329908, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (34959251..35377022, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results show that the RPTPpsi gene is essential for normal functioning of the somitogenesis clock
Title: Receptor tyrosine phosphatase psi is required for Delta/Notch signalling and cyclic gene expression in the presomitic mesoderm.

Submit: New GeneRIF Correction

General gene information

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Markers

fj42a04.x1 (e-PCR)
- UniSTS:199322

fi44e04.y1 (e-PCR)
- UniSTS:197544

fk66g06.x1 (e-PCR)
- UniSTS:201402

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor protein tyrosine phosphatase signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somite specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase U

Names: protein tyrosine phosphatase, receptor type, U, b; receptor-type protein-tyrosine phosphatase psi

NP_001002299.2

EC 3.1.3.48

XP_009290693.1

EC 3.1.3.48

XP_009290694.1

EC 3.1.3.48

XP_009290695.1

EC 3.1.3.48

XP_009290696.1

EC 3.1.3.48

XP_009290697.1

EC 3.1.3.48

XP_009290698.1

EC 3.1.3.48

XP_009290699.1

EC 3.1.3.48

XP_009290700.1

EC 3.1.3.48

XP_009290701.1

EC 3.1.3.48

XP_009290702.1

EC 3.1.3.48

XP_021322308.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002299.2 → NP_001002299.2 receptor-type tyrosine-protein phosphatase U precursor

Status: VALIDATED

Source sequence(s)

BX004992, CR385021, CR926457, FP340271

UniProtKB/Swiss-Prot

B3DK56, Q6E5N7

UniProtKB/TrEMBL

A0A0R4ITF5, A0A8M1N069

Related

ENSDARP00000139263.1, ENSDART00000161729.2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

34913281..35329908 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009292425.3 → XP_009290700.1 receptor-type tyrosine-protein phosphatase U isoform X9

UniProtKB/Swiss-Prot

B3DK56, Q6E5N7

UniProtKB/TrEMBL

A0A8M3AQP8

Conserved Domains (8) summary

cd06263
Location:26 → 182

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00060
Location:282 → 353

FN3; Fibronectin type 3 domain

smart00194
Location:1168 → 1431

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:192 → 278

IG_like; Immunoglobulin like

cd00047
Location:912 → 1136

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:489 → 584

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00102
Location:901 → 1136

Y_phosphatase; Protein-tyrosine phosphatase

pfam00629
Location:26 → 184

MAM; MAM domain, meprin/A5/mu
XM_009292424.3 → XP_009290699.1 receptor-type tyrosine-protein phosphatase U isoform X8

UniProtKB/Swiss-Prot

B3DK56, Q6E5N7

UniProtKB/TrEMBL

A0A2R8QDT0, A0A8M3ATJ2

Related

ENSDARP00000151842.1, ENSDART00000184584.1

Conserved Domains (8) summary

cd06263
Location:26 → 182

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00060
Location:282 → 353

FN3; Fibronectin type 3 domain

smart00194
Location:1169 → 1432

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:192 → 278

IG_like; Immunoglobulin like

cd00047
Location:913 → 1137

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:489 → 584

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00102
Location:902 → 1137

Y_phosphatase; Protein-tyrosine phosphatase

pfam00629
Location:26 → 184

MAM; MAM domain, meprin/A5/mu
XM_009292420.3 → XP_009290695.1 receptor-type tyrosine-protein phosphatase U isoform X3

UniProtKB/Swiss-Prot

B3DK56, Q6E5N7

UniProtKB/TrEMBL

A0A8M3AQP2

Conserved Domains (8) summary

cd06263
Location:26 → 182

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00060
Location:282 → 353

FN3; Fibronectin type 3 domain

smart00194
Location:1178 → 1441

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:192 → 278

IG_like; Immunoglobulin like

cd00047
Location:922 → 1146

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:489 → 584

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00102
Location:911 → 1146

Y_phosphatase; Protein-tyrosine phosphatase

pfam00629
Location:26 → 184

MAM; MAM domain, meprin/A5/mu
XM_021466633.1 → XP_021322308.1 receptor-type tyrosine-protein phosphatase U isoform X6

UniProtKB/Swiss-Prot

B3DK56, Q6E5N7

UniProtKB/TrEMBL

A0A8M9P7S6

Conserved Domains (6) summary

cd06263
Location:26 → 182

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00060
Location:282 → 353

FN3; Fibronectin type 3 domain

smart00410
Location:192 → 278

IG_like; Immunoglobulin like

cd00047
Location:923 → 1140

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:384 → 480

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:489 → 576

fn3; Fibronectin type III domain
XM_009292419.3 → XP_009290694.1 receptor-type tyrosine-protein phosphatase U isoform X2

UniProtKB/Swiss-Prot

B3DK56, Q6E5N7

UniProtKB/TrEMBL

A0A8M3ATI7

Conserved Domains (8) summary

cd06263
Location:26 → 182

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00060
Location:282 → 353

FN3; Fibronectin type 3 domain

smart00194
Location:1178 → 1441

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:192 → 278

IG_like; Immunoglobulin like

cd00047
Location:923 → 1146

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:489 → 584

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00102
Location:923 → 1146

Y_phosphatase; Protein-tyrosine phosphatase

pfam00629
Location:26 → 184

MAM; MAM domain, meprin/A5/mu
XM_009292421.3 → XP_009290696.1 receptor-type tyrosine-protein phosphatase U isoform X4

UniProtKB/Swiss-Prot

B3DK56, Q6E5N7

UniProtKB/TrEMBL

A0A8M3AI73

Conserved Domains (8) summary

cd06263
Location:26 → 182

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00060
Location:282 → 353

FN3; Fibronectin type 3 domain

smart00194
Location:1176 → 1439

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:192 → 278

IG_like; Immunoglobulin like

cd00047
Location:923 → 1144

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:489 → 584

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00102
Location:912 → 1144

Y_phosphatase; Protein-tyrosine phosphatase

pfam00629
Location:26 → 184

MAM; MAM domain, meprin/A5/mu
XM_009292418.3 → XP_009290693.1 receptor-type tyrosine-protein phosphatase U isoform X1

UniProtKB/Swiss-Prot

B3DK56, Q6E5N7

UniProtKB/TrEMBL

A0A286YB08, A0A8M3AJ74

Related

ENSDARP00000144361.1, ENSDART00000174713.2

Conserved Domains (8) summary

cd06263
Location:26 → 182

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00060
Location:282 → 353

FN3; Fibronectin type 3 domain

smart00194
Location:1179 → 1442

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:192 → 278

IG_like; Immunoglobulin like

cd00047
Location:923 → 1147

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:489 → 584

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00102
Location:912 → 1147

Y_phosphatase; Protein-tyrosine phosphatase

pfam00629
Location:26 → 184

MAM; MAM domain, meprin/A5/mu
XM_009292422.3 → XP_009290697.1 receptor-type tyrosine-protein phosphatase U isoform X5

UniProtKB/Swiss-Prot

B3DK56, Q6E5N7

UniProtKB/TrEMBL

A0A0R4INY1, A0A8M3B1S4

Related

ENSDARP00000135991.1, ENSDART00000162518.2

Conserved Domains (8) summary

cd06263
Location:26 → 182

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00060
Location:282 → 353

FN3; Fibronectin type 3 domain

smart00194
Location:1173 → 1436

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:192 → 278

IG_like; Immunoglobulin like

cd00047
Location:923 → 1141

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:489 → 584

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00102
Location:912 → 1141

Y_phosphatase; Protein-tyrosine phosphatase

pfam00629
Location:26 → 184

MAM; MAM domain, meprin/A5/mu
XM_009292427.3 → XP_009290702.1 receptor-type tyrosine-protein phosphatase U isoform X11

UniProtKB/Swiss-Prot

B3DK56, Q6E5N7

UniProtKB/TrEMBL

A0A8M3B1T0

Conserved Domains (8) summary

cd06263
Location:26 → 182

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00060
Location:282 → 353

FN3; Fibronectin type 3 domain

smart00194
Location:1159 → 1422

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:192 → 278

IG_like; Immunoglobulin like

cd00047
Location:912 → 1127

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:489 → 584

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00102
Location:901 → 1127

Y_phosphatase; Protein-tyrosine phosphatase

pfam00629
Location:26 → 184

MAM; MAM domain, meprin/A5/mu
XM_009292426.3 → XP_009290701.1 receptor-type tyrosine-protein phosphatase U isoform X10

UniProtKB/Swiss-Prot

B3DK56, Q6E5N7

UniProtKB/TrEMBL

A0A8M3AI77

Conserved Domains (8) summary

cd06263
Location:26 → 182

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00060
Location:282 → 353

FN3; Fibronectin type 3 domain

smart00194
Location:1162 → 1425

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:192 → 278

IG_like; Immunoglobulin like

cd00047
Location:912 → 1130

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:489 → 584

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00102
Location:901 → 1130

Y_phosphatase; Protein-tyrosine phosphatase

pfam00629
Location:26 → 184

MAM; MAM domain, meprin/A5/mu
XM_009292423.3 → XP_009290698.1 receptor-type tyrosine-protein phosphatase U isoform X7

UniProtKB/Swiss-Prot

B3DK56, Q6E5N7

UniProtKB/TrEMBL

A0A8M3AJ78

Conserved Domains (8) summary

cd06263
Location:26 → 182

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00060
Location:282 → 353

FN3; Fibronectin type 3 domain

smart00194
Location:1172 → 1435

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:192 → 278

IG_like; Immunoglobulin like

cd00047
Location:922 → 1140

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:489 → 584

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00102
Location:911 → 1140

Y_phosphatase; Protein-tyrosine phosphatase

pfam00629
Location:26 → 184

MAM; MAM domain, meprin/A5/mu