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sh3glb1b SH3-domain GRB2-like endophilin B1b [ Danio rerio (zebrafish) ]

Gene ID: 334911, updated on 27-Mar-2024

Summary

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Official Symbol
sh3glb1bprovided by ZNC
Official Full Name
SH3-domain GRB2-like endophilin B1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6851
See related
Ensembl:ENSDARG00000010956 AllianceGenome:ZFIN:ZDB-GENE-030131-6851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sh3glb1; im:5777505; wu:fa08f03; wu:fb13e12
Summary
Predicted to be involved in membrane organization. Predicted to act upstream of or within apoptotic process. Predicted to be located in Golgi membrane and mitochondrial outer membrane. Predicted to be active in membrane. Orthologous to human SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (16174044..16194196)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (16505452..16525606)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene vav 3 guanine nucleotide exchange factor b Neighboring gene selenoprotein J Neighboring gene Rho guanine nucleotide exchange factor (GEF) 4 Neighboring gene APC membrane recruitment protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development. Tallafuss A, et al. Gene Expr Patterns, 2006 Jun. PMID 16448862
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH3-domain GRB2-like endophilin B1; endophilin-B1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256616.1 → NP_001243545.1  endophilin-B1b

    Status: VALIDATED

    Source sequence(s)
    CR788310
    UniProtKB/TrEMBL
    A0A8M1NZI7, B0V151
    Related
    ENSDARP00000045932.6, ENSDART00000045933.7
    Conserved Domains (2) summary
    cd11945
    Location:300 → 360
    SH3_Endophilin_B1; Src homology 3 domain of Endophilin-B1
    cl12013
    Location:21 → 249
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    16174044..16194196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009298264.3 → XP_009296539.1  SH3-domain GRB2-like endophilin B1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3APY9
    Conserved Domains (2) summary
    cd11945
    Location:157 → 217
    SH3_Endophilin_B1; Src homology 3 domain of Endophilin-B1
    cl12013
    Location:35 → 102
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_009298262.3 → XP_009296537.1  SH3-domain GRB2-like endophilin B1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3APC9
    Conserved Domains (2) summary
    cd11945
    Location:341 → 401
    SH3_Endophilin_B1; Src homology 3 domain of Endophilin-B1
    cl12013
    Location:21 → 286
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_005163307.4 → XP_005163364.1  SH3-domain GRB2-like endophilin B1 isoform X2

    UniProtKB/TrEMBL
    A0A0R4IS36, A0A8M2BAQ1
    Related
    ENSDARP00000138573.2, ENSDART00000157601.2
    Conserved Domains (2) summary
    cd11945
    Location:337 → 397
    SH3_Endophilin_B1; Src homology 3 domain of Endophilin-B1
    cl12013
    Location:21 → 286
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. XM_009298263.3 → XP_009296538.1  SH3-domain GRB2-like endophilin B1 isoform X3

    UniProtKB/TrEMBL
    A0A2R8RNA7, A0A8M3B7G3
    Related
    ENSDARP00000149174.1, ENSDART00000190186.1
    Conserved Domains (2) summary
    cd11945
    Location:304 → 364
    SH3_Endophilin_B1; Src homology 3 domain of Endophilin-B1
    cl12013
    Location:21 → 249
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. XM_009298265.3 → XP_009296540.1  SH3-domain GRB2-like endophilin B1 isoform X5

    UniProtKB/TrEMBL
    A0A8M3AZX8
    Conserved Domains (1) summary
    cl12013
    Location:21 → 187
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version

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