eif4g2b eukaryotic translation initiation factor 4, gamma 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eif4g2bprovided by ZNC
Official Full Name: eukaryotic translation initiation factor 4, gamma 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6550
See related: Ensembl:ENSDARG00000057167 AllianceGenome:ZFIN:ZDB-GENE-030131-6550
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: NAT1B; eif4g2; fb44h01; hm:zeh1307; wu:fa14h01; wu:fb44h01; wu:fb59c06; wu:fc21b05
Summary: Predicted to enable mRNA binding activity and translation initiation factor activity. Acts upstream of or within mesoderm development. Predicted to be part of eukaryotic translation initiation factor 4F complex. Orthologous to human EIF4G2 (eukaryotic translation initiation factor 4 gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (16715826..16726206)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (16726760..16737140)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The exclusive use of the non-AUG (GUG) start site for translation initiation of EIF4G2 mRNA is evolutionary conserved in mammals and non-mammals.
Title: Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2).

Submit: New GeneRIF Correction

General gene information

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Markers

fb59c06 (e-PCR)
- UniSTS:187262

fb44h01.x1 (e-PCR)
- UniSTS:203218

AI658292 (e-PCR)
- UniSTS:206075

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 4 gamma 2b

Names: eukaryotic translation initiation factor 4 gamma, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013443.2 → NP_001013461.2 eukaryotic translation initiation factor 4 gamma 2b

Status: VALIDATED

Source sequence(s)

BC109409, EB934789

UniProtKB/TrEMBL

A0A8M1N4J3

Related

ENSDARP00000074210.5, ENSDART00000079758.7

Conserved Domains (3) summary

cd11559
Location:732 → 867

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

smart00544
Location:536 → 649

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

pfam02854
Location:73 → 303

MIF4G; MIF4G domain