prkcda protein kinase C, delta a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prkcdaprovided by ZNC
Official Full Name: protein kinase C, delta aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6503
See related: Ensembl:ENSDARG00000009208 AllianceGenome:ZFIN:ZDB-GENE-030131-6503
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: prkcd; fb09d10; fv43b11; zgc:56558; wu:fb09d10; wu:fv43b11
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within apoptotic process and protein phosphorylation. Located in immunological synapse. Is expressed in blood; myotome; nervous system; otic vesicle; and somite. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; fatty liver disease; and hypertension. Orthologous to human PRKCD (protein kinase C delta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (40523370..40544207)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (40525834..40546671)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell development	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein kinase C, delta a

NP_999873.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214708.1 → NP_999873.1 protein kinase C, delta a

See identical proteins and their annotated locations for NP_999873.1

Status: PROVISIONAL

Source sequence(s)

BC049327

UniProtKB/TrEMBL

A0A8M1PFJ6, Q7ZUC5

Related

ENSDARP00000033971.3, ENSDART00000033819.5

Conserved Domains (3) summary

cd05620
Location:361 → 676

STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta

smart00220
Location:357 → 611

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam00130
Location:232 → 284

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)