hnrnpub heterogeneous nuclear ribonucleoprotein Ub [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hnrnpubprovided by ZNC
Official Full Name: heterogeneous nuclear ribonucleoprotein Ubprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6422
See related: Ensembl:ENSDARG00000004735 AllianceGenome:ZFIN:ZDB-GENE-030131-6422
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hnrpu; hnrnpu; wu:fa66f11; wu:fc18b08; wu:fi89c08; zgc:111835; zgc:136480
Summary: Predicted to enable several functions, including basal RNA polymerase II transcription machinery binding activity; nucleic acid binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including RNA localization to chromatin; regulation of cell cycle process; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleus. Predicted to be part of CRD-mediated mRNA stability complex; catalytic step 2 spliceosome; and telomerase holoenzyme complex. Predicted to be active in several cellular components, including chromosome; microtubule cytoskeleton; and nuclear lumen. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 54. Orthologous to human HNRNPU (heterogeneous nuclear ribonucleoprotein U). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (35058634..35070476)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (35155755..35167597)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi89c08.x1 (e-PCR)
- UniSTS:198171

aa658744 (e-PCR)
- UniSTS:186923

fc18b08.x1 (e-PCR)
- UniSTS:203837

fa10b01.r1 (e-PCR)
- UniSTS:189573

fc64g10.y1 (e-PCR)
- UniSTS:194195

fa66f11 (e-PCR)
- UniSTS:188846

fc48d06.y1 (e-PCR)
- UniSTS:193983

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables promoter-specific chromatin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein Ub

Names: heterogeneous nuclear ribonucleoprotein U; nuclear ribonucleoprotein U-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033595.2 → NP_001028767.2 heterogeneous nuclear ribonucleoprotein Ub

Status: VALIDATED

Source sequence(s)

AL729886, BC117608, BI876648, CT598091, CT600146, CT607270, CT615977, CT625245

UniProtKB/TrEMBL

A0A8M1N7S5, Q1ECZ7, Q5RHQ7

Related

ENSDARP00000112099.2, ENSDART00000122696.5

Conserved Domains (4) summary

smart00513
Location:6 → 40

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam13671
Location:416 → 560

AAA_33; AAA domain

cd12884
Location:205 → 381

SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1

cl17190
Location:416 → 583

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...