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ugp2b UDP-glucose pyrophosphorylase 2b [ Danio rerio (zebrafish) ]

Gene ID: 334420, updated on 27-Mar-2024

Summary

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Official Symbol
ugp2bprovided by ZNC
Official Full Name
UDP-glucose pyrophosphorylase 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6352
See related
Ensembl:ENSDARG00000008200 AllianceGenome:ZFIN:ZDB-GENE-030131-6352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Ugp2; fi53h10; zgc:85662; wu:fi53h10
Summary
Predicted to enable UTP:glucose-1-phosphate uridylyltransferase activity. Involved in larval locomotory behavior. Predicted to be active in cytoplasm. Is expressed in epidermis; notochord; polster; pronephric duct; and ventral mesoderm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ugp2b in Genome Data Viewer
Location:
chromosome: 17
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (24445545..24471062)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (24427144..24452188)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene WD repeat containing planar cell polarity effector Neighboring gene malate dehydrogenase 1Ab, NAD (soluble) Neighboring gene pellino E3 ubiquitin protein ligase 1b Neighboring gene ATP-binding cassette, sub-family H, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases. Perenthaler E, et al. Acta Neuropathol, 2020 Mar. PMID 31820119, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables UTP:glucose-1-phosphate uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UTP:glucose-1-phosphate uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within UDP-glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in larval locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UDP-glucose pyrophosphorylase 2b; UTP--glucose-1-phosphate uridylyltransferase
Names
UDP-glucose pyrophosphorylase 2
NP_001303819.1
NP_997894.2
XP_005158553.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316890.1 → NP_001303819.1  UDP-glucose pyrophosphorylase 2b isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CR352220, EH433688
    UniProtKB/TrEMBL
    A0A8M1P748
    Related
    ENSDARP00000115076.1, ENSDART00000139963.3
    Conserved Domains (1) summary
    pfam01704
    Location:103 → 519
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

  2. NM_212729.2 → NP_997894.2  UDP-glucose pyrophosphorylase 2b isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and distinct 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    CR352220, DT081919
    UniProtKB/TrEMBL
    A0A8M1PLK9, F1QDY2
    Related
    ENSDARP00000123568.1, ENSDART00000140467.3
    Conserved Domains (1) summary
    pfam01704
    Location:55 → 471
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    24445545..24471062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158496.4 → XP_005158553.1  UTP--glucose-1-phosphate uridylyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A0R4IBN4, A0A8M2B4X0
    Related
    ENSDARP00000129923.1, ENSDART00000163221.3
    Conserved Domains (1) summary
    pfam01704
    Location:59 → 475
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394990.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    1749..26793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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