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Tfb4 Transcription factor B4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33294, updated on 4-Apr-2024

Summary

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Official Symbol
Tfb4provided by FlyBase
Official Full Name
Transcription factor B4provided by FlyBase
Primary source
FLYBASE:FBgn0031309
Locus tag
Dmel_CG5041
See related
AllianceGenome:FB:FBgn0031309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5041; Dmel\CG5041; Dmp34; p34; TFB4
Summary
Predicted to be involved in several processes, including nucleotide-excision repair; phosphorylation of RNA polymerase II C-terminal domain; and transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Is expressed in organism. Orthologous to human GTF2H3 (general transcription factor IIH subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Tfb4 in Genome Data Viewer
Location:
21F1-21F1; 2-2 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1149445..1150677, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1149445..1150677, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45717 Neighboring gene Major Facilitator Superfamily Transporter 3 Neighboring gene lethal (2) 10685 Neighboring gene Vacuolar protein sorting 29 Neighboring gene capulet Neighboring gene antisense RNA:CR43767 Neighboring gene Transport and Golgi organization 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila. Villicaña C, et al. J Cell Sci, 2013 Jun 1. PMID 23549790
  2. A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer. Stettler K, et al. Dis Model Mech, 2015 Jan. PMID 25431422, Free PMC Article
  3. p8/TTDA overexpression enhances UV-irradiation resistance and suppresses TFIIH mutations in a Drosophila trichothiodystrophy model. Aguilar-Fuentes J, et al. PLoS Genet, 2008 Nov. PMID 19008953, Free PMC Article
  4. RNA polymerase II 140wimp mutant and mutations in the TFIIH subunit XPB differentially affect homeotic gene expression in Drosophila. Gutiérrez L, et al. Genesis, 2004 Sep. PMID 15354295
  5. Genes encoding Drosophila melanogaster RNA polymerase II general transcription factors: diversity in TFIIA and TFIID components contributes to gene-specific transcriptional regulation. Aoyagi N, et al. J Cell Biol, 2000 Jul 24. PMID 10908585, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in RNA polymerase II promoter clearance ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in response to UV ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transcription open complex formation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of transcription factor TFIIH core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH core complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH core complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
transcription factor B4
Names
CG5041-PA
TFB4 ortholog
Tfb4-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    1149445..1150677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134730.3 → NP_608574.2  transcription factor B4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608574.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZ89, Q9VPX4
    Related
    FBpp0077650
    Conserved Domains (1) summary
    pfam03850
    Location:15 → 276
    Tfb4; Transcription factor Tfb4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SZ89 Q8SZ89
Q9VPX4 Q9VPX4

Gene LinkOut

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