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Clp Clipper [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33259, updated on 10-May-2024

Summary

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Official Symbol
Clpprovided by FlyBase
Official Full Name
Clipperprovided by FlyBase
Primary source
FLYBASE:FBgn0015621
Locus tag
Dmel_CG3642
See related
AllianceGenome:FB:FBgn0015621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
c6a; CG3642; clp; CLP; Cpsf30; CPSF30; Dmel\CG3642; Ssb-c6a
Summary
Enables endoribonuclease activity. Predicted to be involved in pre-mRNA cleavage required for polyadenylation. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in follicle cell; oocyte; organism; and ovary. Orthologous to several human genes including CPSF4 (cleavage and polyadenylation specific factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
21E2-21E2; 2-1.5 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (819964..821209)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (819964..821209)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Peroxin 12 Neighboring gene uncharacterized protein Neighboring gene Post-GPI attachment to proteins 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene dreadlocks

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila clipper/CPSF 30K is a post-transcriptionally regulated nuclear protein that binds RNA containing GC clusters. Bai C, et al. Nucleic Acids Res, 1998 Apr 1. PMID 9512528, Free PMC Article
  2. Cleavage of RNA hairpins mediated by a developmentally regulated CCCH zinc finger protein. Bai C, et al. Mol Cell Biol, 1996 Dec. PMID 8943320, Free PMC Article
  3. RNA- and single-stranded DNA-binding (SSB) proteins expressed during Drosophila melanogaster oogenesis: a homolog of bacterial and eukaryotic mitochondrial SSBs. Stroumbakis ND, et al. Gene, 1994 Jun 10. PMID 8206370
  4. A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs. Sullivan KD, et al. Mol Cell, 2009 May 15. PMID 19450530, Free PMC Article
  5. Use of circular RNAs as markers of readthrough transcription to identify factors regulating cleavage/polyadenylation events. Liang D, et al. Methods, 2021 Dec. PMID 33882363, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
clipper
Names
CG3642-PA
Clp-PA
single stranded-binding protein c6a

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    819964..821209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057808.2 → NP_477156.1  clipper [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477156.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0JQ42, Q24081, Q9VPT8
    Related
    FBpp0077676, FBtr0078011
    Conserved Domains (2) summary
    smart00356
    Location:66 → 90
    ZnF_C3H1; zinc finger
    COG5084
    Location:12 → 175
    YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPT8.1 Q9VPT8

Gene LinkOut

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