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Rpt6 Regulatory particle triple-A ATPase 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33105, updated on 5-May-2024

Summary

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Official Symbol
Rpt6provided by FlyBase
Official Full Name
Regulatory particle triple-A ATPase 6provided by FlyBase
Primary source
FLYBASE:FBgn0020369
Locus tag
Dmel_CG1489
See related
AllianceGenome:FB:FBgn0020369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1489; CG1489; Dmel\CG1489; Dm_Rpt6a; dRpt6; Dug; DUG; p42C; pros45; Pros45; PRS8_DROME; S8; sug-1; sug1; Ug
Summary
Predicted to enable proteasome-activating activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Part of proteasome regulatory particle, base subcomplex. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval nervous system; presumptive embryonic/larval system; and primordial germ cell. Orthologous to human PSMC5 (proteasome 26S subunit, ATPase 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
19F4-19F4; 1-65 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21316052..21317663)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21187079..21188690)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 3 Neighboring gene transfer RNA:Tyrosine-GTA 1-1 Neighboring gene transfer RNA:Tyrosine-GTA 2-1 Neighboring gene uncharacterized protein Neighboring gene SRA stem-loop interacting RNA binding protein 1 Neighboring gene anorexia Neighboring gene Dullard

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of Pros45, the Drosophila SUG1 proteasome subunit homolog. Cheng L, et al. Mol Gen Genet, 1998 Jul. PMID 9738875
  2. Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila. Uechi H, et al. Mol Cell Biol, 2018 Feb 1. PMID 29109084, Free PMC Article
  3. Correct dosage of X chromosome transcription is controlled by a nuclear pore component. Aleman JR, et al. Cell Rep, 2021 Jun 15. PMID 34133927, Free PMC Article
  4. cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis. Ojelade SA, et al. Cell Rep, 2019 Aug 13. PMID 31412248, Free PMC Article
  5. Molecular characterization of the Rpt1/p48B ATPase subunit of the Drosophila melanogaster 26S proteasome. Szabó A, et al. Mol Genet Genomics, 2007 Jul. PMID 17429695

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome-activating activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, base subcomplex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, base subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
regulatory particle triple-A ATPase 6
Names
26S proteasome regulatory subunit 8
CG1489-PA
Pros45
Rpt6-PA
p42C
proteasomal subunit 8
NP_608447.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    21316052..21317663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134603.2 → NP_608447.1  regulatory particle triple-A ATPase 6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608447.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18413, O45023
    Related
    FBpp0076890
    Conserved Domains (4) summary
    COG1222
    Location:17 → 403
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
    pfam00004
    Location:185 → 317
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam13191
    Location:152 → 205
    AAA_16; AAA ATPase domain
    cl01090
    Location:27 → 69
    SlyX; SlyX
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18413.2 O18413

Gene LinkOut

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