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Acsbg2 acyl-CoA synthetase bubblegum family member 2 [ Mus musculus (house mouse) ]

Gene ID: 328845, updated on 21-Apr-2024

Summary

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Official Symbol
Acsbg2provided by MGI
Official Full Name
acyl-CoA synthetase bubblegum family member 2provided by MGI
Primary source
MGI:MGI:3587728
See related
Ensembl:ENSMUSG00000024207 AllianceGenome:MGI:3587728
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bgr
Summary
Enables long-chain fatty acid-CoA ligase activity. Acts upstream of or within fatty acid metabolic process. Located in cytosol. Orthologous to human ACSBG2 (acyl-CoA synthetase bubblegum family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 66.3) See more
Orthologs
human all
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Genomic context

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Location:
17 D; 17 29.54 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57150103..57181505, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56843103..56874505, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene proline rich 22 Neighboring gene regulatory factor X, 2 (influences HLA class II expression) Neighboring gene predicted gene, 41604 Neighboring gene STARR-positive B cell enhancer ABC_E5625 Neighboring gene STARR-seq mESC enhancer starr_42905 Neighboring gene STARR-seq mESC enhancer starr_42911 Neighboring gene acyl-CoA synthetase bubblegum family member 3 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 Neighboring gene STARR-positive B cell enhancer ABC_E1946

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis. Fraisl P, et al. Arch Biochem Biophys, 2006 Jul 1. PMID 16762313
  2. The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase. Pei Z, et al. J Biol Chem, 2006 Mar 10. PMID 16371355
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The limited tissue expression pattern and limited substrate specificity rule out a likely role for this enzyme in X-linked adrenoleukodystrophy pathology.
    Title: The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid beta-oxidation IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase ACSBG2
Names
arachidonate--CoA ligase ACSBG2
bubblegum-related protein
NP_001034203.1
XP_006524506.1
XP_006524507.1
XP_011244805.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039114.1 → NP_001034203.1  long-chain-fatty-acid--CoA ligase ACSBG2

    See identical proteins and their annotated locations for NP_001034203.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ250679
    Consensus CDS
    CCDS28916.1
    UniProtKB/Swiss-Prot
    Q2XU92
    Related
    ENSMUSP00000042352.5, ENSMUST00000043062.5
    Conserved Domains (1) summary
    cd05933
    Location:69 → 665
    ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57150103..57181505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246503.3 → XP_011244805.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X2

    See identical proteins and their annotated locations for XP_011244805.1

    Conserved Domains (1) summary
    cl17068
    Location:2 → 473
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. XM_006524444.2 → XP_006524507.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X2

    See identical proteins and their annotated locations for XP_006524507.1

    Conserved Domains (1) summary
    cl17068
    Location:2 → 473
    AFD_class_I; Adenylate forming domain, Class I superfamily

  3. XM_006524443.4 → XP_006524506.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1

    Conserved Domains (1) summary
    cl17068
    Location:69 → 560
    AFD_class_I; Adenylate forming domain, Class I superfamily

RNA

  1. XR_003952137.1 RNA Sequence

  2. XR_001782082.2 RNA Sequence

  3. XR_003952138.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2XU92.1 GenPept UniProtKB/Swiss-Prot:Q2XU92

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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