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Prps1l3 phosphoribosyl pyrophosphate synthetase 1-like 3 [ Mus musculus (house mouse) ]

Gene ID: 328099, updated on 11-Apr-2024

Summary

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Official Symbol
Prps1l3provided by MGI
Official Full Name
phosphoribosyl pyrophosphate synthetase 1-like 3provided by MGI
Primary source
MGI:MGI:3779453
See related
Ensembl:ENSMUSG00000079104 AllianceGenome:MGI:3779453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm5081; AU021838; AW536152
Summary
Predicted to enable ATP binding activity; protein homodimerization activity; and ribose phosphate diphosphokinase activity. Predicted to be involved in several processes, including 5-phosphoribose 1-diphosphate biosynthetic process; purine-containing compound biosynthetic process; and urate biosynthetic process. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 10.5), placenta adult (RPKM 10.4) and 28 other tissues See more
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Genomic context

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Location:
12 C1; 12 24.7 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (57277198..57288954)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (57230412..57242168)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 Neighboring gene STARR-seq mESC enhancer starr_32215 Neighboring gene STARR-seq mESC enhancer starr_32216 Neighboring gene predicted gene, 30001 Neighboring gene STARR-seq mESC enhancer starr_32218 Neighboring gene STARR-seq mESC enhancer starr_32219 Neighboring gene STARR-positive B cell enhancer ABC_E7135 Neighboring gene predicted gene, 40426 Neighboring gene mirror-image polydactyly 1 Neighboring gene serum/glucocorticoid regulated kinase 1 pseudogene Neighboring gene predicted gene 16246

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet. Kondoh S, et al. J Hum Genet, 2002. PMID 11954550
  2. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117905

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribose phosphate diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribose phosphate diphosphokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribose-phosphate pyrophosphokinase
NP_001032835.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037746.3 → NP_001032835.2  ribose-phosphate pyrophosphokinase

    Status: VALIDATED

    Source sequence(s)
    AK032842, AK134500, AW552637, CA544687
    Consensus CDS
    CCDS56839.1
    UniProtKB/TrEMBL
    G3UXL2, Q3TI27, Q3UPD5
    Related
    ENSMUSP00000133736.2, ENSMUST00000139049.2
    Conserved Domains (3) summary
    COG0462
    Location:1 → 313
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    pfam13793
    Location:4 → 120
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    cl00309
    Location:161 → 313
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    57277198..57288954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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