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CG8142 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32763, updated on 4-Apr-2024

Summary

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Official Symbol
CG8142provided by FlyBase
Primary source
FLYBASE:FBgn0030871
Locus tag
Dmel_CG8142
See related
AllianceGenome:FB:FBgn0030871
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG8142; DmRFC2; RfC; RFC2; Rfc37; rfc4
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and DNA binding activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in DNA repair and DNA-dependent DNA replication. Part of Elg1 RFC-like complex. Is expressed in several structures, including embryonic brain; embryonic/larval midgut; embryonic/larval nervous system; extended germ band embryo; and ventral ectoderm. Orthologous to human RFC4 (replication factor C subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
16E1-16E1; 1-59 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17843343..17844704, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17737376..17738737, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Suppressor of Cytokine Signaling at 16D Neighboring gene long non-coding RNA:CR44691 Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 9 Neighboring gene Uncoupling protein 4A Neighboring gene uncharacterized protein Neighboring gene Spt7 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants. Krause SA, et al. Mol Cell Biol, 2001 Aug. PMID 11438670, Free PMC Article
  2. Transcriptional regulation of the Drosophila rfc1 gene by the DRE-DREF pathway. Tsuchiya A, et al. FEBS J, 2007 Apr. PMID 17381512
  3. The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition. Huang F, et al. Genes Dev, 2016 May 15. PMID 27198229, Free PMC Article
  4. Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila. Kind J, et al. Cell, 2008 May 30. PMID 18510926
  5. HP1 modulates the transcription of cell-cycle regulators in Drosophila melanogaster. De Lucia F, et al. Nucleic Acids Res, 2005. PMID 15905474, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Elg1 RFC-like complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8142-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17843343..17844704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133017.4 → NP_573245.1  uncharacterized protein Dmel_CG8142 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573245.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T033, Q9VX15
    Related
    FBpp0074246
    Conserved Domains (4) summary
    cd00009
    Location:45 → 187
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    PRK00440
    Location:31 → 344
    rfc; replication factor C small subunit; Reviewed
    pfam08542
    Location:293 → 344
    Rep_fac_C; Replication factor C C-terminal domain
    pfam16193
    Location:211 → 256
    AAA_assoc_2; AAA C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VX15 Q9VX15

Gene LinkOut

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