mapkapk2a MAPK activated protein kinase 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mapkapk2aprovided by ZNC
Official Full Name: MAPK activated protein kinase 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5532
See related: Ensembl:ENSDARG00000002552 AllianceGenome:ZFIN:ZDB-GENE-030131-5532
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mapkapk2; wu:fb30e10; wu:fc56c10; wu:fi03a01
Summary: Enables kinase activity. Acts upstream of or within epiboly involved in gastrulation with mouth forming second. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (21154678..21218076, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (20994110..21057508, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a p38 MAPKAPK2 kinase cascade modulates the activity of F-actin at the yolk cell margin circumference allowing the gradual closure of the blastopore as epiboly progresses
Title: A novel role for MAPKAPK2 in morphogenesis during zebrafish development.

Submit: New GeneRIF Correction

General gene information

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Markers

fb75d05.x1 (e-PCR)
- UniSTS:191240

fb75d05.x1 (e-PCR)
- UniSTS:191241

fb30e10 (e-PCR)
- UniSTS:189010

fi03a01.x1 (e-PCR)
- UniSTS:196597

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mitogen-activated protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to vascular endothelial growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: MAP kinase-activated protein kinase 2

Names: bbp; betty boop; mitogen-activated protein kinase-activated protein kinase 2; mitogen-activated protein kinase-activated protein kinase 2a

NP_958460.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201303.1 → NP_958460.1 MAP kinase-activated protein kinase 2

See identical proteins and their annotated locations for NP_958460.1

Status: PROVISIONAL

Source sequence(s)

BC054572

UniProtKB/TrEMBL

A0A8N1Z3B3, Q7T2F2

Related

ENSDARP00000020470.8, ENSDART00000027532.9

Conserved Domains (2) summary

smart00220
Location:49 → 306

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14170
Location:42 → 344

STKc_MAPKAPK2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2