wee1 WEE1 G2 checkpoint kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wee1provided by ZNC
Official Full Name: WEE1 G2 checkpoint kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5268
See related: Ensembl:ENSDARG00000093864 AllianceGenome:ZFIN:ZDB-GENE-030131-5268
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa20h03; wu:fa20h03; zgc:136514
Summary: Predicted to enable protein tyrosine kinase activity. Acts upstream of or within response to light stimulus. Predicted to be active in nucleus. Orthologous to human WEE1 (WEE1 G2 checkpoint kinase). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 18

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (16918426..16923727, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (16929360..16934661, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1, p21, PCNA and cdk2, but only weakly influences cyclin B1, cyclin B2 and cyclin E1 expression.
Title: Circadian clock regulation of the cell cycle in the zebrafish intestine.
the data suggests that fin regeneration in zebrafish is regulated by both environmental cues and functional gene expressions. Alterations in lighting conditions or inhibition of wee1 expression result in decreases in fin regeneration after injury.
Title: Effects of light illumination and the expression of wee1 on tissue regeneration in adult zebrafish.
Light-dependent activation of Fos/AP-1 induces the expression of zWee1, a cell cycle gene essential for G2/M transition.
Title: Common pathways in circadian and cell cycle clocks: light-dependent activation of Fos/AP-1 in zebrafish controls CRY-1a and WEE-1.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fi49a08.y1 (e-PCR)
- UniSTS:197633

fa20h03.s1 (e-PCR)
- UniSTS:202471

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to light stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: wee1-like protein kinase

Names: WEE1 homolog

NP_001296364.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309435.1 → NP_001296364.1 wee1-like protein kinase

Status: VALIDATED

Source sequence(s)

BX005395

UniProtKB/TrEMBL

A0A8M1P766, Q1LYE1, Q6DRI0

Related

ENSDARP00000105540.2, ENSDART00000122102.3

Conserved Domains (2) summary

pfam00069
Location:265 → 534

Pkinase; Protein kinase domain

cl21453
Location:259 → 533

PKc_like; Protein Kinases, catalytic domain