tmed10 transmembrane p24 trafficking protein 10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tmed10provided by ZNC
Official Full Name: transmembrane p24 trafficking protein 10provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4915
See related: Ensembl:ENSDARG00000041391 AllianceGenome:ZFIN:ZDB-GENE-030131-4915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TMP21; fe06g04; zgc:85681; wu:fb98e10; wu:fe06g04
Summary: Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in axis; hatching gland; notochord; pancreas; and polster. Orthologous to human TMED10 (transmembrane p24 trafficking protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (46536598..46541843, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (46632878..46638123, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tmed10 deficiency results in impaired exocrine pancreatic differentiation in zebrafish larvae.
Title: Tmed10 deficiency results in impaired exocrine pancreatic differentiation in zebrafish larvae.

Submit: New GeneRIF Correction

General gene information

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Markers

fb98e10.x1 (e-PCR)
- UniSTS:203619

AW174879 (e-PCR)
- UniSTS:205801

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cargo receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in COPII-coated ER to Golgi transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane emp24 domain-containing protein 10

Names: p24 delta 1; transmembrane emp24-like trafficking protein 10; transmembrane trafficking protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310040.1 → NP_001296969.1 transmembrane emp24 domain-containing protein 10 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in its central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

BX936455, EH520370, EH525843, EH541878, EH611403

UniProtKB/TrEMBL

A0A2R8QEQ4, A0A8M1P7E1

Related

ENSDARP00000153388.1, ENSDART00000181720.1

Conserved Domains (1) summary

pfam01105
Location:22 → 201

EMP24_GP25L; emp24/gp25L/p24 family/GOLD
NM_214698.2 → NP_999863.1 transmembrane emp24 domain-containing protein 10 isoform 1 precursor

See identical proteins and their annotated locations for NP_999863.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BX936455, EH520370, EH525843, EH541878, EH611403

UniProtKB/TrEMBL

Q6NWI7, Q6PC27

Related

ENSDARP00000060684.3, ENSDART00000060685.4

Conserved Domains (1) summary

pfam01105
Location:22 → 203

EMP24_GP25L; emp24/gp25L/p24 family/GOLD