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eIF2alpha eukaryotic translation initiation factor 2 subunit alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32617, updated on 27-Mar-2024

Summary

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Official Symbol
eIF2alphaprovided by FlyBase
Official Full Name
eukaryotic translation initiation factor 2 subunit alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0261609
Locus tag
Dmel_CG9946
See related
AllianceGenome:FB:FBgn0261609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9946; deIF2alpha; Dmel\CG9946; eIF-2; eIF-2 a; eIF-2 alpha; eiF-2alpha; eIF-2alpha; EIF-2alpha; eIF-2alphaeIF-2alpha; eIF2 alpha; eIF2-alpha; eIF2a; Eif2alpha; EIF2alpha; Elf; elF2alpha; IF2A_DROME; l(1)14Cf; l(1)19-153; M(1)14C; M(1)19-153; M(1)8e3-10; P-eIF2alpha
Summary
Enables translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Predicted to be part of several cellular components, including eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 2 complex; and eukaryotic translation initiation factor 2B complex. Is expressed in adult head; adult heart; and ovary. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
14C6-14C6; 1-53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16445176..16446993, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16339209..16341026, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene hangover Neighboring gene Cell division cycle 50 Neighboring gene rings lost Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 4H1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell autonomous and non-autonomous consequences of deviations in translation machinery on organism growth and the connecting signalling pathways. Surya A, et al. Open Biol, 2022 Apr. PMID 35472285, Free PMC Article
  2. Isolation and characterization of the Drosophila melanogaster eIF-2 alpha gene encoding the alpha subunit of translation initiation factor eIF-2. Qu S, et al. Gene, 1994 Mar 25. PMID 8144032
  3. PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila. Elvira R, et al. Int J Mol Sci, 2020 Jan 28. PMID 32013014, Free PMC Article
  4. Reduced Sleep During Social Isolation Leads to Cellular Stress and Induction of the Unfolded Protein Response. Brown MK, et al. Sleep, 2017 Jul 1. PMID 28541519, Free PMC Article
  5. Characterization of Fragile X Mental Retardation Protein granules formation and dynamics in Drosophila. Gareau C, et al. Biol Open, 2013 Jan 15. PMID 23336078, Free PMC Article

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2alpha.
    Title: Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α.
  2. PERK-Mediated eIF2alpha Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila.
    Title: PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila.
  3. Therapeutic modulation of eIF2alpha phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.
    Title: Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of eukaryotic 48S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of eukaryotic translation initiation factor 2B complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 2 subunit alpha
Names
CG9946-PA
CG9946-PB
eIF-2alpha
eIF2alpha-PA
eIF2alpha-PB
eukaryotic initiation factor 2alpha
eukaryotic translation initiation factor 2
eukaryotic translation initiation factor 2alpha
minute (1) 14C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16445176..16446993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298400.1 → NP_001285329.1  eukaryotic translation initiation factor 2 subunit alpha, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285329.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41374, Q9V3G2
    UniProtKB/TrEMBL
    X2JFR6
    Conserved Domains (3) summary
    COG1093
    Location:6 → 278
    SUI2; Translation initiation factor 2, alpha subunit (eIF-2alpha) [Translation, ribosomal structure and biogenesis]
    cd04452
    Location:13 → 88
    S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
    pfam07541
    Location:130 → 239
    EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit

  2. NM_132902.4 → NP_573130.1  eukaryotic translation initiation factor 2 subunit alpha, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573130.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41374, Q9V3G2
    UniProtKB/TrEMBL
    X2JFR6
    Related
    FBpp0074075
    Conserved Domains (3) summary
    COG1093
    Location:6 → 278
    SUI2; Translation initiation factor 2, alpha subunit (eIF-2alpha) [Translation, ribosomal structure and biogenesis]
    cd04452
    Location:13 → 88
    S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
    pfam07541
    Location:130 → 239
    EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41374.1 P41374
X2JFR6 X2JFR6

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