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src v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog [ Danio rerio (zebrafish) ]

Gene ID: 325084, updated on 11-Apr-2024

Summary

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Official Symbol
srcprovided by ZNC
Official Full Name
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3809
See related
Ensembl:ENSDARG00000008107 AllianceGenome:ZFIN:ZDB-GENE-030131-3809
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
c-src; fc54g04; p60-Src; sb:cb864; wu:fc54g04
Summary
Predicted to enable growth factor receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within posterior lateral line neuromast primordium migration; regulation of vascular permeability; and response to yeast. Predicted to be located in several cellular components, including focal adhesion; mitochondrial inner membrane; and perinuclear region of cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including adaxial cell; central nervous system; musculature system; periderm; and retina. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 23
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (39346891..39455070)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (39453979..39560022)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells 2a Neighboring gene potassium voltage-gated channel, subfamily G, member 1 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 1 Neighboring gene calcium/calmodulin-dependent protein kinase IGb

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion. Gallardo VE, et al. Dis Model Mech, 2015 Jun. PMID 25810455, Free PMC Article
  2. A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies. Turro E, et al. Sci Transl Med, 2016 Mar 2. PMID 26936507, Free PMC Article
  3. Identification of Novel Anti-Liver Cancer Small Molecules with Better Therapeutic Index than Sorafenib via Zebrafish Drug Screening Platform. Lin HS, et al. Cancers (Basel), 2019 May 28. PMID 31141996, Free PMC Article
  4. Microexon-based regulation of ITSN1 and Src SH3 domains specificity relies on introduction of charged amino acids into the interaction interface. Dergai M, et al. Biochem Biophys Res Commun, 2010 Aug 20. PMID 20659428
  5. Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability. Hoeppner LH, et al. Blood, 2012 Sep 13. PMID 22674805, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Src-Tks5 pathway is required for neural crest cell migration during embryonic development
    Title: A Src-Tks5 pathway is required for neural crest cell migration during embryonic development.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within posterior lateral line neuromast primordium migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in progesterone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of vascular permeability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proto-oncogene tyrosine-protein kinase Src
Names
pp60c-src
protein-tyrosine kinase
proto-oncogene c-Src
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
NP_001003837.2
XP_005174187.1
XP_017209008.1
XP_017209009.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003837.2 → NP_001003837.2  proto-oncogene tyrosine-protein kinase Src

    See identical proteins and their annotated locations for NP_001003837.2

    Status: PROVISIONAL

    Source sequence(s)
    BC116544
    UniProtKB/Swiss-Prot
    Q1JPZ3, Q6EWH0
    UniProtKB/TrEMBL
    B2GS52
    Related
    ENSDARP00000093618.4, ENSDART00000102843.5
    Conserved Domains (4) summary
    cd10365
    Location:145 → 245
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd05071
    Location:258 → 534
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    pfam07714
    Location:268 → 517
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:85 → 142
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    39346891..39455070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017353519.2 → XP_017209008.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/Swiss-Prot
    Q1JPZ3, Q6EWH0
    UniProtKB/TrEMBL
    A0A8M6Z3N7

  2. XM_017353520.2 → XP_017209009.1  proto-oncogene tyrosine-protein kinase Src isoform X2

    UniProtKB/Swiss-Prot
    Q1JPZ3, Q6EWH0
    UniProtKB/TrEMBL
    A0A8M6YVT4

  3. XM_005174130.4 → XP_005174187.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    UniProtKB/Swiss-Prot
    Q1JPZ3, Q6EWH0
    UniProtKB/TrEMBL
    A0A2R8QE56, A0A8M2BLD8
    Related
    ENSDARP00000152013.1, ENSDART00000190985.1
    Conserved Domains (4) summary
    cd10365
    Location:151 → 251
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd05071
    Location:264 → 540
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    pfam07714
    Location:274 → 523
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:85 → 148
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1JPZ3.2 GenPept UniProtKB/Swiss-Prot:Q1JPZ3

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