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sp8b sp8 transcription factor b [ Danio rerio (zebrafish) ]

Gene ID: 324931, updated on 27-Mar-2024

Summary

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Official Symbol
sp8bprovided by ZNC
Official Full Name
sp8 transcription factor bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3654
See related
Ensembl:ENSDARG00000056666 AllianceGenome:ZFIN:ZDB-GENE-030131-3654
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Sp8; Sp8a; sp8l; fc48e06; zgc:77258; wu:fc48e06
Summary
Enables double-stranded DNA binding activity. Involved in embryonic limb morphogenesis. Acts upstream of or within embryonic pectoral fin morphogenesis and positive regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including apical ectodermal ridge pelvic fin bud; midbrain neural keel; nervous system; neural plate; and neural tube. Orthologous to human SP8 (Sp8 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 16
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (19534100..19539774)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (19730779..19733846)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:dkey-233k19.3 Neighboring gene uncharacterized LOC101885538 Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 5 Neighboring gene uncharacterized LOC108179597

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genomic structure and cloning of two transcript isoforms of human Sp8. Milona MA, et al. BMC Genomics, 2004 Nov 8. PMID 15533246, Free PMC Article
  2. Pur alpha and Sp8 as opposing regulators of neural gata2 expression. Penberthy WT, et al. Dev Biol, 2004 Nov 1. PMID 15464585
  3. An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra. Vogg MC, et al. Nat Commun, 2019 Jan 18. PMID 30659200, Free PMC Article
  4. Genetic basis of hindlimb loss in a naturally occurring vertebrate model. Don EK, et al. Biol Open, 2016 Feb 18. PMID 26892237, Free PMC Article
  5. Allometric growth of the trunk leads to the rostral shift of the pelvic fin in teleost fishes. Murata Y, et al. Dev Biol, 2010 Nov 1. PMID 20692249

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic pectoral fin morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor Sp8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205550.2 → NP_991113.1  transcription factor Sp8

    See identical proteins and their annotated locations for NP_991113.1

    Status: PROVISIONAL

    Source sequence(s)
    AY591904
    UniProtKB/Swiss-Prot
    Q6ED30, Q6P0J3
    UniProtKB/TrEMBL
    A0A8M9P7R9
    Related
    ENSDARP00000101509.2, ENSDART00000112894.3
    Conserved Domains (3) summary
    sd00017
    Location:302 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:357 → 379
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:343 → 366
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    19534100..19539774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466623.1 → XP_021322298.1  transcription factor Sp8 isoform X2

    UniProtKB/Swiss-Prot
    Q6ED30, Q6P0J3
    UniProtKB/TrEMBL
    A0A8M9P7R9
    Conserved Domains (3) summary
    sd00017
    Location:302 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:357 → 379
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:343 → 366
    zf-H2C2_2; Zinc-finger double domain

  2. XM_005157958.4 → XP_005158015.1  transcription factor Sp8 isoform X1

    See identical proteins and their annotated locations for XP_005158015.1

    UniProtKB/TrEMBL
    A0A8M2B498, Q3L0W2
    Related
    ENSDARP00000073657.5, ENSDART00000079201.6
    Conserved Domains (3) summary
    sd00017
    Location:320 → 339
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:375 → 397
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:361 → 384
    zf-H2C2_2; Zinc-finger double domain

  3. XM_005157959.4 → XP_005158016.1  transcription factor Sp8 isoform X2

    See identical proteins and their annotated locations for XP_005158016.1

    UniProtKB/Swiss-Prot
    Q6ED30, Q6P0J3
    UniProtKB/TrEMBL
    A0A8M9P7R9
    Conserved Domains (3) summary
    sd00017
    Location:302 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:357 → 379
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:343 → 366
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P0J3.1 GenPept UniProtKB/Swiss-Prot:Q6P0J3

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