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ptprna protein tyrosine phosphatase receptor type Na [ Danio rerio (zebrafish) ]

Gene ID: 324790, updated on 11-Apr-2024

Summary

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Official Symbol
ptprnaprovided by ZNC
Official Full Name
protein tyrosine phosphatase receptor type Naprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3511
See related
Ensembl:ENSDARG00000058646 AllianceGenome:ZFIN:ZDB-GENE-030131-3511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
IA-2; ptprn; fc43c04; wu:fc43c04
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in secretory granule; synapse; and transport vesicle membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine phosphatase receptor type N). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See ptprna in Genome Data Viewer
Location:
chromosome: 9
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (7548502..7619626)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (7570111..7641235)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 198a Neighboring gene desmin a Neighboring gene microRNA 153c Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene tubulin, alpha 8 like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated Cornelia de Lange syndrome in vitro and in vivo. Cukrov D, et al. Hum Mol Genet, 2018 Sep 1. PMID 29860495
  2. CRISPRz: a database of zebrafish validated sgRNAs. Varshney GK, et al. Nucleic Acids Res, 2016 Jan 4. PMID 26438539, Free PMC Article
  3. The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish. Cai T, et al. Diabetologia, 2001 Jan. PMID 11206415
  4. Zebrafish as a model to study PTPs during development. Paardekooper Overman J, et al. Methods, 2014 Jan 15. PMID 23974070
  5. High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Varshney GK, et al. Genome Res, 2015 Jul. PMID 26048245, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin secretion involved in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein tyrosine phosphatase receptor type Na; protein tyrosine phosphatase, receptor type, Na
Names
protein tyrosine phosphatase, receptor type, N
NP_001124060.2
XP_017213141.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130588.2 → NP_001124060.2  protein tyrosine phosphatase receptor type Na precursor

    Status: VALIDATED

    Source sequence(s)
    CU639452, CU861474
    UniProtKB/TrEMBL
    A0A8M1NL05, F1R8X1
    Related
    ENSDARP00000075984.4, ENSDART00000081543.5
    Conserved Domains (5) summary
    smart00194
    Location:633 → 892
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:660 → 892
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam10152
    Location:284 → 370
    DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)
    pfam11548
    Location:395 → 480
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:47 → 105
    RESP18; RESP18 domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    7548502..7619626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017357652.2 → XP_017213141.1  protein tyrosine phosphatase, receptor type, Na isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z8D6
Nucleotide Protein
Heading Accession and Version

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