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ercc3 excision repair cross-complementation group 3 [ Danio rerio (zebrafish) ]

Gene ID: 324323, updated on 27-Mar-2024

Summary

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Official Symbol
ercc3provided by ZNC
Official Full Name
excision repair cross-complementation group 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3043
See related
Ensembl:ENSDARG00000002402 AllianceGenome:ZFIN:ZDB-GENE-030131-3043
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc25f08
Summary
Predicted to enable 3'-5' DNA helicase activity. Predicted to be involved in apoptotic process and nucleic acid metabolic process. Predicted to act upstream of or within nucleotide-excision repair. Predicted to be located in nucleus. Predicted to be part of nucleotide-excision repair factor 3 complex; transcription factor TFIIH holo complex; and transcription preinitiation complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (9595417..9630081, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (9359878..9394542, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 2 Neighboring gene cytochrome P450, family 27, subfamily C, polypeptide 1 Neighboring gene WD repeat domain 12 Neighboring gene transcription factor 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary conservation of TFIIH subunits: implications for the use of zebrafish as a model to study TFIIH function and regulation. Silva IA, et al. Comp Biochem Physiol B Biochem Mol Biol, 2014 Jun-Jul. PMID 24731924
  2. Selection of reliable biomarkers from PCR array analyses using relative distance computational model: methodology and proof-of-concept study. Liu C, et al. PLoS One, 2013. PMID 24349563, Free PMC Article
  3. Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. Webb KJ, et al. Genome Biol, 2009. PMID 19646228, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA topological change ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription-coupled nucleotide-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of nucleotide-excision repair factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
general transcription and DNA repair factor IIH helicase subunit XPB
Names
DNA excision repair protein ERCC-3
TFIIH basal transcription factor complex helicase XPB subunit
TFIIH subunit XPB
excision repair cross-complementing rodent repair deficiency, complementation group 3
xpb
NP_963876.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201582.1 → NP_963876.1  general transcription and DNA repair factor IIH helicase subunit XPB

    See identical proteins and their annotated locations for NP_963876.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045400
    UniProtKB/Swiss-Prot
    Q7ZVV1
    UniProtKB/TrEMBL
    B2GSW0
    Related
    ENSDARP00000010637.7, ENSDART00000013066.8
    Conserved Domains (4) summary
    TIGR00603
    Location:58 → 779
    rad25; DNA repair helicase rad25
    pfam04851
    Location:314 → 471
    ResIII; Type III restriction enzyme, res subunit
    pfam13625
    Location:74 → 196
    Helicase_C_3; Helicase conserved C-terminal domain
    pfam16203
    Location:495 → 733
    ERCC3_RAD25_C; ERCC3/RAD25/XPB C-terminal helicase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    9595417..9630081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZVV1.1 GenPept UniProtKB/Swiss-Prot:Q7ZVV1

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