U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

orc6 origin recognition complex, subunit 6 [ Danio rerio (zebrafish) ]

Gene ID: 324256, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
orc6provided by ZNC
Official Full Name
origin recognition complex, subunit 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2976
See related
Ensembl:ENSDARG00000075682 AllianceGenome:ZFIN:ZDB-GENE-030131-2976
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
orc6l; zgc:65798; zgc:77185; wu:fa94a09; wu:fc22h10
Summary
Predicted to enable DNA binding activity. Acts upstream of or within cilium assembly. Predicted to be located in nucleus. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in central nervous system; eye; intermediate cell mass of mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 3. Orthologous to human ORC6 (origin recognition complex subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 7
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (41812513..41821361)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (41532440..41541288)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene histamine receptor H3 Neighboring gene VPS35 retromer complex component Neighboring gene myosin light chain kinase 3 Neighboring gene zgc:92818 Neighboring gene glutamic pyruvate transaminase (alanine aminotransferase) 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors. Maerz LD, et al. Eur J Hum Genet, 2019 May. PMID 30696958, Free PMC Article
  2. Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors. Idilli AI, et al. Cancers (Basel), 2020 Apr 22. PMID 32331249, Free PMC Article
  3. DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Jacob V, et al. Development, 2015 Feb 1. PMID 25564650, Free PMC Article
  4. Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Leontovich AA, et al. J Diabetes Res, 2016. PMID 26981540, Free PMC Article
  5. Telomerase Is Essential for Zebrafish Heart Regeneration. Bednarek D, et al. Cell Rep, 2015 Sep 8. PMID 26321646, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear origin of replication recognition complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
origin recognition complex subunit 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212671.2 → NP_997836.1  origin recognition complex subunit 6

    See identical proteins and their annotated locations for NP_997836.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056528
    UniProtKB/TrEMBL
    Q6P0G9, Q6ZM36
    Related
    ENSDARP00000101426.2, ENSDART00000113732.3
    Conserved Domains (2) summary
    cd11583
    Location:93 → 184
    Orc6_mid; Middle domain of the origin recognition complex subunit 6
    pfam05460
    Location:6 → 93
    ORC6; Origin recognition complex subunit 6 (ORC6)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    41812513..41821361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.