sp1 sp1 transcription factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sp1provided by ZNC
Official Full Name: sp1 transcription factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2829
See related: Ensembl:ENSDARG00000088347 AllianceGenome:ZFIN:ZDB-GENE-030131-2829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc18h09; zgc:85950; wu:fc18h09
Summary: Enables DNA-binding transcription factor activity and double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in brain; liver; spinal cord; and testis. Orthologous to human SP1 (Sp1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (19668..29152, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (6642..28130, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a, sp1 and sod1 in zebrafish.
Title: Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
Title: Zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1.

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General gene information

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Markers

fc18h09.x1 (e-PCR)
- UniSTS:192903

fc18h09.x1 (e-PCR)
- UniSTS:192904

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryo development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor Sp1

Names: Sp1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212662.2 → NP_997827.2 transcription factor Sp1

Status: VALIDATED

Source sequence(s)

CK139903, FP326665

UniProtKB/TrEMBL

A0A8M1PHF3, F1QW97

Related

ENSDARP00000110200.1, ENSDART00000124104.2

Conserved Domains (4) summary

COG5048
Location:465 → 547

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:452 → 474

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:510 → 532

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:496 → 519

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007122.7 Reference GRCz11 Primary Assembly

Range

19668..29152 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479551.1 → XP_021335226.1 transcription factor Sp1 isoform X1

UniProtKB/TrEMBL

A0A8M6Z917

Conserved Domains (3) summary

sd00017
Location:429 → 451

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:487 → 509

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:473 → 496

zf-H2C2_2; Zinc-finger double domain
XM_017358202.1 → XP_017213691.1 transcription factor Sp1 isoform X1

UniProtKB/TrEMBL

A0A8M6Z917

Conserved Domains (3) summary

sd00017
Location:429 → 451

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:487 → 509

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:473 → 496

zf-H2C2_2; Zinc-finger double domain