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Prp16 pre-mRNA processing factor 16 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32373, updated on 10-May-2024

Summary

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Official Symbol
Prp16provided by FlyBase
Official Full Name
pre-mRNA processing factor 16provided by FlyBase
Primary source
FLYBASE:FBgn0026713
Locus tag
Dmel_CG32604
See related
AllianceGenome:FB:FBgn0026713
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1375; cg1405; CG1405; CG32604; Dmel\CG32604; EP764; EP784; l(1)G0007; l(1)G0028; l(1)G0103; l(1)G0176; l(1)G0308; l(1)G0416; l(1)G0476; l(1)G0491; lethal (1) G0007; prp16
Summary
Predicted to enable RNA binding activity and RNA helicase activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Is expressed in several structures, including embryonic brain; embryonic/larval nervous system; extended germ band embryo; ventral ectoderm; and visceral muscle primordium. Human ortholog(s) of this gene implicated in retinitis pigmentosa 84. Orthologous to human DHX38 (DEAH-box helicase 38). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
12E3-12E5; 1-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14201362..14224732)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14095395..14118765)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene yolkless Neighboring gene mir-4917 stem loop Neighboring gene uncharacterized protein Neighboring gene lethal (1) G0469 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L38 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of alternative splicing by signal-dependent degradation of splicing-regulatory proteins. Katzenberger RJ, et al. J Biol Chem, 2009 Apr 17. PMID 19218244, Free PMC Article
  2. Novel perspectives of target-binding by the evolutionarily conserved PP4 phosphatase. Karman Z, et al. Open Biol, 2020 Dec. PMID 33352067, Free PMC Article
  3. Body size in Drosophila: genetic architecture, allometries and sexual dimorphism. Carreira VP, et al. Heredity (Edinb), 2009 Mar. PMID 19018274
  4. Tracing the origin of the compensasome: evolutionary history of DEAH helicase and MYST acetyltransferase gene families. Sanjuán R, et al. Mol Biol Evol, 2001 Mar. PMID 11230534
  5. Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. Andersen DS, et al. J Biol Chem, 2008 Nov 7. PMID 18765666, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3'-5' RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
pre-mRNA processing factor 16
Names
CG32604-PA
CG32604-PB
Prp16-PA
Prp16-PB
lethal (1) G0007
NP_572947.1
NP_727764.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    14201362..14224732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132719.3 → NP_572947.1  pre-mRNA processing factor 16, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572947.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TT2, Q9VY54
    Related
    FBpp0073717
    Conserved Domains (5) summary
    smart00487
    Location:529 → 715
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:932 → 1014
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:551 → 689
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:722 → 870
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam07717
    Location:1048 → 1148
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  2. NM_167396.2 → NP_727764.1  pre-mRNA processing factor 16, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727764.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VY50
    Related
    FBpp0073718
    Conserved Domains (5) summary
    smart00847
    Location:244 → 326
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:1 → 444
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00079
    Location:34 → 182
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam07717
    Location:360 → 460
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    pfam14265
    Location:474 → 515
    DUF4355; Domain of unknown function (DUF4355)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VY50 Q9VY50
Q9VY54 Q9VY54

Gene LinkOut

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