cav1 caveolin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cav1provided by ZNC
Official Full Name: caveolin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2415
See related: Ensembl:ENSDARG00000103747 AllianceGenome:ZFIN:ZDB-GENE-030131-2415
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc07c04
Summary: Enables beta-catenin binding activity. Acts upstream of or within several processes, including animal organ development; regionalization; and regulation of defense response. Predicted to be located in Golgi membrane and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to colocalize with caveola; focal adhesion; and sarcolemma. Is expressed in several structures, including cardiovascular system; ectoderm; integument; lateral line system; and tail bud. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); lipodystrophy (multiple); primary open angle glaucoma; primary pulmonary hypertension; and systemic scleroderma (multiple). Orthologous to human CAV1 (caveolin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (18563476..18575505)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (18467076..18479105)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Injury-induced Cavl-expressing cells at lesion rostral side play major roles in spinal cord regeneration.
Title: Injury-induced Cavl-expressing cells at lesion rostral side play major roles in spinal cord regeneration.
These results point to intestinal epithelial cell CAV1 as a potential therapeutic target to lower circulating free fatty acids and LDL cholesterol.
Title: Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels.
Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.
Title: Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.
The development of transgenic zebrafish lines expressing CLTA fused to dsRed and CAV1 fused to GFP is reported.
Title: Novel transgenic lines to fluorescently label clathrin and caveolin endosomes in live zebrafish.
maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin
Title: Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish.
These results support important and previously unanticipated roles for the Caveolin-1 isoforms in vertebrate organogenesis.
Title: Caveolin-1alpha and -1beta perform nonredundant roles in early vertebrate development.

Submit: New GeneRIF Correction

General gene information

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Markers

fb95c12.x1 (e-PCR)
- UniSTS:191876

fb95c12.x1 (e-PCR)
- UniSTS:191877

fc37c03.x1 (e-PCR)
- UniSTS:193704

fc07c04.x1 (e-PCR)
- UniSTS:203749

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in caveola assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within caveola assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within caveola assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intestinal cholesterol absorption	IPI Inferred from Physical Interaction more info
involved_in negative regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord cell vacuolation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with caveola	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with sarcolemma	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: caveolin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.