alox12 arachidonate 12-lipoxygenase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: alox12provided by ZNC
Official Full Name: arachidonate 12-lipoxygenaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1452
See related: Ensembl:ENSDARG00000069463 AllianceGenome:ZFIN:ZDB-GENE-030131-1452
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:64120; wu:fb72a11
Summary: Enables arachidonate 12(S)-lipoxygenase activity and calcium ion binding activity. Predicted to be involved in fatty acid metabolic process and lipid oxidation. Located in nucleus. Is expressed in several structures, including EVL; digestive system; epidermal cell; epidermis; and periderm. Orthologous to several human genes including ALOX12 (arachidonate 12-lipoxygenase, 12S type). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (26029733..26047946)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (25758540..25776753)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes.
Title: 12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes.
A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish.
Title: A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fc16d12.x1 (e-PCR)
- UniSTS:192789

fb72a11.x1 (e-PCR)
- UniSTS:191079

fb72a11.x1 (e-PCR)
- UniSTS:191080

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables arachidonate 12(S)-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate 12(S)-lipoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate 12(S)-lipoxygenase activity	IEA Inferred from Electronic Annotation more info
enables arachidonate 12(S)-lipoxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables arachidonate 15-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables linoleate 13S-lipoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid oxidation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid oxidation	IEA Inferred from Electronic Annotation more info
involved_in lipoxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: arachidonate 12-lipoxygenase, 12S-type

Names: ALOX1; LOX1

NP_955912.1

EC 1.13.11.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199618.1 → NP_955912.1 arachidonate 12-lipoxygenase, 12S-type

See identical proteins and their annotated locations for NP_955912.1

Status: PROVISIONAL

Source sequence(s)

BC054621

UniProtKB/TrEMBL

A0A8M1P9T6, Q7T2A9

Related

ENSDARP00000091900.3, ENSDART00000101126.5

Conserved Domains (2) summary

cd01753
Location:1 → 115

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

pfam00305
Location:227 → 649

Lipoxygenase; Lipoxygenase