rpl3 ribosomal protein L3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rpl3provided by ZNC
Official Full Name: ribosomal protein L3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1291
See related: Ensembl:ENSDARG00000003599 AllianceGenome:ZFIN:ZDB-GENE-030131-1291
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fa99g02; wu:fb65e09; zgc:110350
Summary: Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within exocrine pancreas development. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in eye; liver; and pancreas. Used to study Shwachman-Diamond syndrome. Orthologous to human RPL3 (ribosomal protein L3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (29867225..29871348, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (29736383..29740506, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown or mutation of either rpl3 or pes resulted in impaired expansion of pancreatic progenitor cells.
Title: Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development.

Submit: New GeneRIF Correction

General gene information

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Markers

fa99g02.x1 (e-PCR)
- UniSTS:202639

AI544741 (e-PCR)
- UniSTS:206306

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 60S ribosomal protein L3

NP_001001590.1

EC 3.6.5.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001590.1 → NP_001001590.1 60S ribosomal protein L3

See identical proteins and their annotated locations for NP_001001590.1

Status: PROVISIONAL

Source sequence(s)

AY561514

UniProtKB/TrEMBL

A0A2R8Q924, Q5BJJ2, Q6Q418

Related

ENSDARP00000003700.7, ENSDART00000011251.10

Conserved Domains (2) summary

PTZ00103
Location:1 → 400

PTZ00103; 60S ribosomal protein L3; Provisional

cl00324
Location:3 → 375

RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]