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pola2 polymerase (DNA directed), alpha 2 [ Danio rerio (zebrafish) ]

Gene ID: 322059, updated on 11-Apr-2024

Summary

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Official Symbol
pola2provided by ZNC
Official Full Name
polymerase (DNA directed), alpha 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-778
See related
Ensembl:ENSDARG00000015070 AllianceGenome:ZFIN:ZDB-GENE-030131-778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56124; zgc:77841; wu:fb48f05
Summary
Predicted to enable DNA binding activity. Acts upstream of or within with a positive effect on cell population proliferation and fin regeneration. Predicted to be located in nucleus. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (17174795..17184516, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (17139083..17148804, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene centromere protein H Neighboring gene alpha-ketoglutarate dehydrogenase subunit 4 Neighboring gene DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) Neighboring gene v-ski avian sarcoma viral oncogene homolog a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The RNA helicase Ddx52 functions as a growth switch in juvenile zebrafish. Tseng TL, et al. Development, 2021 Aug 1. PMID 34323273, Free PMC Article
  2. Genetic Reprogramming of Positional Memory in a Regenerating Appendage. Wang YT, et al. Curr Biol, 2019 Dec 16. PMID 31786062, Free PMC Article
  3. Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients. Mans DA, et al. J Pathol, 2013 Sep. PMID 23744542
  4. Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Leontovich AA, et al. J Diabetes Res, 2016. PMID 26981540, Free PMC Article
  5. Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. Kuil LE, et al. Elife, 2020 May 5. PMID 32367800, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within_positive_effect cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect fin regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA polymerase alpha subunit B
Names
polymerase (DNA-directed), alpha (70kD)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199581.2 → NP_955875.2  DNA polymerase alpha subunit B

    Status: VALIDATED

    Source sequence(s)
    BC065460, BX465215, EH494906, EH521232, EH582754, EH606241
    UniProtKB/TrEMBL
    A0A8M1PBJ8, B0S687, Q6P0S9
    Related
    ENSDARP00000002618.6, ENSDART00000025803.7
    Conserved Domains (2) summary
    pfam04042
    Location:346 → 550
    DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    pfam08418
    Location:23 → 246
    Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    17174795..17184516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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