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nono non-POU domain containing, octamer-binding [ Danio rerio (zebrafish) ]

Gene ID: 321994, updated on 11-Apr-2024

Summary

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Official Symbol
nonoprovided by ZNC
Official Full Name
non-POU domain containing, octamer-bindingprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-713
See related
Ensembl:ENSDARG00000020482 AllianceGenome:ZFIN:ZDB-GENE-030131-713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb40d10; wu:fc11d05
Summary
Predicted to enable RNA binding activity. Acts upstream of or within central nervous system development; otic vesicle development; and somite development. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 34. Orthologous to human NONO (non-POU domain containing octamer binding). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See nono in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (22593624..22603354, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (22089824..22099559, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor (ligand) superfamily, member 10 like 4 Neighboring gene caspase 22, apoptosis-related cysteine peptidase Neighboring gene zgc:113208 Neighboring gene melatonin receptor 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A universal cloning method based on yeast homologous recombination that is simple, efficient, and versatile. Joska TM, et al. J Microbiol Methods, 2014 May. PMID 24418681, Free PMC Article
  2. Evaluation of toxicological endpoints in female zebrafish after bisphenol A exposure. Molina AM, et al. Food Chem Toxicol, 2018 Feb. PMID 29258955
  3. Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain. Huang L, et al. Sci Rep, 2019 Feb 12. PMID 30755680, Free PMC Article
  4. Large-scale discovery of novel genetic causes of developmental disorders. Deciphering Developmental Disorders Study. Nature, 2015 Mar 12. PMID 25533962, Free PMC Article
  5. Identification of nodal signaling targets by array analysis of induced complex probes. Dickmeis T, et al. Dev Dyn, 2001 Dec. PMID 11748827

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within otic vesicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
non-POU domain-containing octamer-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201579.1 → NP_963873.1  non-POU domain-containing octamer-binding protein

    See identical proteins and their annotated locations for NP_963873.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046880
    UniProtKB/TrEMBL
    A0A8M2BCB1, Q802Z5
    Related
    ENSDARP00000014106.5, ENSDART00000011699.7
    Conserved Domains (3) summary
    cd12947
    Location:217 → 310
    NOPS_p54nrb; NOPS domain, including C-terminal coiled-coil region, in 54 kDa nuclear RNA- and DNA-binding protein (p54nrb) and similar proteins
    cd12591
    Location:147 → 226
    RRM2_p54nrb; RNA recognition motif 2 in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
    cl17169
    Location:71 → 141
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    22593624..22603354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165105.4 → XP_005165162.1  non-POU domain-containing octamer-binding protein isoform X1

    See identical proteins and their annotated locations for XP_005165162.1

    UniProtKB/TrEMBL
    A0A8M2BCB1, Q802Z5
    Conserved Domains (3) summary
    cd12947
    Location:217 → 310
    NOPS_p54nrb; NOPS domain, including C-terminal coiled-coil region, in 54 kDa nuclear RNA- and DNA-binding protein (p54nrb) and similar proteins
    cd12591
    Location:147 → 226
    RRM2_p54nrb; RNA recognition motif 2 in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
    cl17169
    Location:71 → 141
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_021476008.1 → XP_021331683.1  non-POU domain-containing octamer-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A8M9PX41
    Conserved Domains (3) summary
    cd12947
    Location:217 → 310
    NOPS_p54nrb; NOPS domain, including C-terminal coiled-coil region, in 54 kDa nuclear RNA- and DNA-binding protein (p54nrb) and similar proteins
    cd12591
    Location:147 → 226
    RRM2_p54nrb; RNA recognition motif 2 in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
    cl17169
    Location:71 → 141
    RRM_SF; RNA recognition motif (RRM) superfamily

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394573.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    109185..122898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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