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hnrnpaba heterogeneous nuclear ribonucleoprotein A/Ba [ Danio rerio (zebrafish) ]

Gene ID: 321466, updated on 11-Apr-2024

Summary

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Official Symbol
hnrnpabaprovided by ZNC
Official Full Name
heterogeneous nuclear ribonucleoprotein A/Baprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-185
See related
Ensembl:ENSDARG00000007960 AllianceGenome:ZFIN:ZDB-GENE-030131-185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hnrpab; hnrnpab; zeh1271; sqd-likeA; hm:zeh1271; wu:fa18g02; wu:fb07b06; wu:fb16c05
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Predicted to be active in nucleoplasm. Is expressed in several structures, including EVL; digestive system; fin; nervous system; and periderm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human HNRNPAB (heterogeneous nuclear ribonucleoprotein A/B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 14
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (6962255..6966131)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (6655553..6659404)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene receptor for activated C kinase 1 Neighboring gene NME/NM23 family member 5 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3, like Neighboring gene heterogeneous nuclear ribonucleoprotein H1 Neighboring gene RUN and FYVE domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The expression of CPEB proteins is sequentially regulated during zebrafish oogenesis and embryogenesis. O'Connell ML, et al. Mol Reprod Dev, 2014 Apr. PMID 24474627
  2. Impacts of triclosan exposure on zebrafish early-life stage: Toxicity and acclimation mechanisms. Falisse E, et al. Aquat Toxicol, 2017 Aug. PMID 28605648
  3. Analysis of the zebrafish proteome during embryonic development. Lucitt MB, et al. Mol Cell Proteomics, 2008 May. PMID 18212345, Free PMC Article
  4. Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Vejnar CE, et al. Genome Res, 2019 Jul. PMID 31227602, Free PMC Article
  5. Analysis of protein expression in developmental toxicity induced by MeHg in zebrafish. Cuello S, et al. Analyst, 2012 Nov 21. PMID 23014190

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein A/B; heterogeneous nuclear ribonucleoprotein A/Ba

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212587.3 → NP_997752.2  heterogeneous nuclear ribonucleoprotein A/Ba

    See identical proteins and their annotated locations for NP_997752.2

    Status: VALIDATED

    Source sequence(s)
    BC066454
    UniProtKB/TrEMBL
    A0A8N7XJ29, F8W4E3, Q4QRD8, Q6NYU8
    Related
    ENSDARP00000124217.2, ENSDART00000148447.3
    Conserved Domains (3) summary
    cd12584
    Location:149 → 228
    RRM2_hnRNPAB; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    cd12757
    Location:70 → 144
    RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    pfam08143
    Location:1 → 69
    CBFNT; CBFNT (NUC161) domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    6962255..6966131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169577.2 → XP_005169634.1  heterogeneous nuclear ribonucleoprotein A/B isoform X1

    UniProtKB/TrEMBL
    A0A8M2BHF1
    Conserved Domains (3) summary
    cd12584
    Location:149 → 228
    RRM2_hnRNPAB; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    cd12757
    Location:70 → 144
    RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    pfam08143
    Location:1 → 69
    CBFNT; CBFNT (NUC161) domain
Nucleotide Protein Strain
Heading Accession and Version

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