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quo quattro [ Danio rerio (zebrafish) ]

Gene ID: 321031, updated on 27-Mar-2024

Summary

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Official Symbol
quoprovided by ZNC
Official Full Name
quattroprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9944
See related
Ensembl:ENSDARG00000073684 AllianceGenome:ZFIN:ZDB-GENE-030131-9944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb9; sb:cb9; fb97g10; wu:fb97g10
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within animal organ morphogenesis and mesoderm morphogenesis. Is expressed in several structures, including Kupffer's vesicle; anterior axial hypoblast; forerunner cell group; mesoderm; and nervous system. Orthologous to human KIAA1755 (KIAA1755). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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Location:
chromosome: 6
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (2030703..2092501)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (1895787..1958835)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene homeobox protein TGIF2-like Neighboring gene discs, large (Drosophila) homolog-associated protein 4b Neighboring gene transglutaminase 2b Neighboring gene V-set and transmembrane domain containing 2 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain. Tse SW, et al. Gene, 2005 Oct 10. PMID 16143467
  2. Developmentally restricted actin-regulatory molecules control morphogenetic cell movements in the zebrafish gastrula. Daggett DF, et al. Curr Biol, 2004 Sep 21. PMID 15380064
  3. Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach. von der Heyde B, et al. Sci Rep, 2020 Jul 16. PMID 32678143, Free PMC Article
  4. Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish. Wang X, et al. Biol Open, 2013. PMID 24244857, Free PMC Article
  5. TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish. Fillatre J, et al. Elife, 2019 Sep 12. PMID 31513014, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesoderm morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
quattro

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004109.2 → NP_001004109.2  quattro

    Status: VALIDATED

    Source sequence(s)
    CU634004, FO905048, FP236186
    UniProtKB/TrEMBL
    Q6DN89
    Related
    ENSDARP00000099241.3, ENSDART00000109679.4
    Conserved Domains (3) summary
    cd13242
    Location:1673 → 1808
    PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
    pfam00621
    Location:1507 → 1680
    RhoGEF; RhoGEF domain
    cl25732
    Location:894 → 1314
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    2030703..2092501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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