Idi2 isopentenyl-diphosphate delta isomerase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Idi2provided by MGI
Official Full Name: isopentenyl-diphosphate delta isomerase 2provided by MGI
Primary source: MGI:MGI:2444315
See related: Ensembl:ENSMUSG00000033520 AllianceGenome:MGI:2444315
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IPPI2; 4833405L16Rik
Summary: Predicted to enable isopentenyl-diphosphate delta-isomerase activity. Acts upstream of or within negative regulation of cholesterol biosynthetic process. Predicted to be located in peroxisome. Predicted to be active in cytoplasm. Orthologous to human IDI2 (isopentenyl-diphosphate delta isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 13 A1; 13 3.63 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (9002899..9010981)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (8952863..8960935)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

significant positive fitness effect of IDI2, revealed by the pattern of sequence conservation, as well as its specific expression pattern underscores the importance of the IDI gene duplication
Title: Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables isopentenyl-diphosphate delta-isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables isopentenyl-diphosphate delta-isomerase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isopentenyl diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within isopentenyl diphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in isoprenoid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cholesterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: isopentenyl-diphosphate delta-isomerase 2

Names: IPP isomerase 2; isopentenyl diphosphate delta-isomerase type 2; isopentenyl pyrophosphate isomerase 2; isopentenyl-diphosphate Delta-isomerase 2

NP_796171.1

EC 5.3.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177197.5 → NP_796171.1 isopentenyl-diphosphate delta-isomerase 2

See identical proteins and their annotated locations for NP_796171.1

Status: VALIDATED

Source sequence(s)

AC124732

Consensus CDS

CCDS26235.1

UniProtKB/Swiss-Prot

Q4FZF0, Q8BFZ6

Related

ENSMUSP00000036621.2, ENSMUST00000038598.3

Conserved Domains (2) summary

COG1443
Location:18 → 215

Idi; Isopentenyldiphosphate isomerase [Lipid transport and metabolism]

cl00447
Location:18 → 227

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...