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Dpep2 dipeptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 319446, updated on 21-Apr-2024

Summary

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Official Symbol
Dpep2provided by MGI
Official Full Name
dipeptidase 2provided by MGI
Primary source
MGI:MGI:2442042
See related
Ensembl:ENSMUSG00000053687 Ensembl:ENSMUSG00000115067 AllianceGenome:MGI:2442042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MBD-2; F630103D06Rik
Summary
Enables dipeptidase activity. Involved in leukotriene metabolic process. Is anchored component of membrane. Orthologous to human DPEP2 (dipeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 5.2), mammary gland adult (RPKM 2.9) and 13 other tissues See more
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Genomic context

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Location:
8 D3; 8 53.07 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106711577..106732658, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105984945..106006026, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 4 Neighboring gene microRNA 7074 Neighboring gene STARR-seq mESC enhancer starr_22546 Neighboring gene predicted gene 45752 Neighboring gene dipeptidase 3 Neighboring gene predicted gene, 22972 Neighboring gene DEAD box helicase 28 Neighboring gene dihydrouridine synthase 2 Neighboring gene STARR-positive B cell enhancer ABC_E1375 Neighboring gene STARR-positive B cell enhancer ABC_E3801 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108636517-108636718 Neighboring gene epithelial splicing regulatory protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dpep2 Emerging as a Modulator of Macrophage Inflammation Confers Protection Against CVB3-Induced Viral Myocarditis. Yang X, et al. Front Cell Infect Microbiol, 2019. PMID 30899700, Free PMC Article
  2. Identification of two additional members of the membrane-bound dipeptidase family. Habib GM, et al. FASEB J, 2003 Jul. PMID 12738806
  3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Taken together, this study revealed that Dpep2 could protect against Coxsackievirus B3-induced viral myocarditis by acting as a suppressor of macrophage inflammation.
    Title: Dpep2 Emerging as a Modulator of Macrophage Inflammation Confers Protection Against CVB3-Induced Viral Myocarditis.
  2. cloning and characterization of membrane-bound dipeptidase-2 and membrane-bound dipeptidase-3
    Title: Identification of two additional members of the membrane-bound dipeptidase family.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dipeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dipeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables exopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in leukotriene D4 catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dipeptidase 2
Names
membrane-bound dipeptidase 2
putative membrane-bound dipeptidase 2
NP_001288133.1
NP_001288134.1
NP_795887.2
XP_006531144.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301204.1 → NP_001288133.1  dipeptidase 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001288133.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the most abundant transcript and encodes isoform 1.
    Source sequence(s)
    AK171503, BX634751, BY209853
    Consensus CDS
    CCDS80926.1
    UniProtKB/Swiss-Prot
    Q3TAV9, Q3TBF7, Q3TBK3, Q3TBM9, Q7TQ53, Q8C255
    UniProtKB/TrEMBL
    A0A2K6EDK8
    Related
    ENSMUSP00000034373.8, ENSMUST00000034373.8
    Conserved Domains (1) summary
    pfam01244
    Location:80 → 401
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  2. NM_001301205.1 → NP_001288134.1  dipeptidase 2 isoform 2

    See identical proteins and their annotated locations for NP_001288134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK171503, BX634751, BY209853
    Consensus CDS
    CCDS80925.1
    UniProtKB/Swiss-Prot
    Q8C255
    Related
    ENSMUSP00000113877.2, ENSMUST00000117555.8
    Conserved Domains (1) summary
    pfam01244
    Location:1 → 308
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  3. NM_176913.4 → NP_795887.2  dipeptidase 2 isoform 3

    See identical proteins and their annotated locations for NP_795887.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence, contains three alternate splice junctions, and contains an alternate 3' coding exon compared to variant 1. The resulting isoform (3) is longer at the N-terminus and has internal differences compared to isoform 1. This variant appears to be found rarely in nature.
    Source sequence(s)
    AF488552, AK171503, BX634751
    Consensus CDS
    CCDS22625.1
    UniProtKB/TrEMBL
    A0A2K6EDK8
    Related
    ENSMUSP00000080659.7, ENSMUST00000081998.13
    Conserved Domains (1) summary
    pfam01244
    Location:166 → 501
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106711577..106732658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531081.4 → XP_006531144.1  dipeptidase 2 isoform X1

    UniProtKB/TrEMBL
    A0A2K6EDK8
    Conserved Domains (1) summary
    pfam01244
    Location:213 → 534
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C255.1 GenPept UniProtKB/Swiss-Prot:Q8C255

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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