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HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 [ Homo sapiens (human) ]

Gene ID: 3187, updated on 7-Apr-2024

Summary

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Official Symbol
HNRNPH1provided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein H1provided by HGNC
Primary source
HGNC:HGNC:5041
See related
Ensembl:ENSG00000169045 MIM:601035; AllianceGenome:HGNC:5041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRPH; HNRPH1; NEDCDS; hnRNPH
Summary
This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in bone marrow (RPKM 153.8), lymph node (RPKM 101.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See HNRNPH1 in Genome Data Viewer
Location:
5q35.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (179614178..179634784, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (180168628..180189994, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (179041179..179061785, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC128966623 Neighboring gene RUN and FYVE domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:178998880-178999380 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:179003374-179004573 Neighboring gene peroxiredoxin 2 pseudogene 3 Neighboring gene RUFY1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:179033750-179034250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:179034251-179034751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23754 Neighboring gene Sharpr-MPRA regulatory region 11836 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179051499-179052283 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:179059505-179060005 Neighboring gene chromosome 5 open reading frame 60-like Neighboring gene chromosome 5 open reading frame 60

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing. Pararajalingam P, et al. Blood, 2020 Jul 30. PMID 32160292, Free PMC Article
  2. Serum exosomal hnRNPH1 mRNA as a novel marker for hepatocellular carcinoma. Xu H, et al. Clin Chem Lab Med, 2018 Feb 23. PMID 29252188
  3. Protein and gene expression characteristics of heterogeneous nuclear ribonucleoprotein H1 in esophageal squamous cell carcinoma. Sun YL, et al. World J Gastroenterol, 2016 Aug 28. PMID 27621578, Free PMC Article
  4. Mapping of primary congenital lymphedema to the 5q35.3 region. Evans AL, et al. Am J Hum Genet, 1999 Feb. PMID 9973292, Free PMC Article
  5. Variants in HNRNPH1 are associated with high myopia in humans and ocular coloboma in zebrafish. Ouyang J, et al. Clin Genet, 2022 Nov. PMID 35989590

See all (334) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Variants in HNRNPH1 are associated with high myopia in humans and ocular coloboma in zebrafish.
    Title: Variants in HNRNPH1 are associated with high myopia in humans and ocular coloboma in zebrafish.
  2. A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia.
    Title: A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia.
  3. Burkitt lymphoma-related TCF3 mutations alter TCF3 alternative splicing by disrupting hnRNPH1 binding.
    Title: Burkitt lymphoma-related TCF3 mutations alter TCF3 alternative splicing by disrupting hnRNPH1 binding.
  4. Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing.
    Title: Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing.
  5. Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1.
    Title: Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1.
  6. demonstrate that hnRNP H1 and PTBP1 regulate TCF3 AS reciprocally, and that position-dependent interactions between these factors are essential for proper TCF3 MEAS
    Title: TCF3 mutually exclusive alternative splicing is controlled by long-range cooperative actions between hnRNPH1 and PTBP1.
  7. LINC00162 overexpression increased the sensitivity, enhanced cell cycle arrest and apoptosis induced by 5-aza-dC, but did not affect its DNA demethylation effect. Mechanistically, LINC00162 interacted with an RNA splicing protein, HNRNPH1, and decreased splicing of an anti-apoptotic splicing variant, BCL-XL. LINC00162 may have translational value to predict patients who will respond to 5-aza-dC.
    Title: LINC00162 confers sensitivity to 5-Aza-2'-deoxycytidine via modulation of an RNA splicing protein, HNRNPH1.
  8. this study is the first to identify hnRNP F/H and K as regulators of Mcl-1 alternative splicing.
    Title: Regulation of Mcl-1 alternative splicing by hnRNP F, H1 and K in breast cancer cells.
  9. Sequestration of hnRNP H altered the splicing of target transcripts in C9 amyotrophic lateral sclerosis patients with GGGGCC expansion in the C9ORF72 gene. Here, the show that this signature also occurs in half of 50 postmortem sporadic, amyotrophic lateral sclerosis/frontotemporal dementia brains lacking GGGGCC expansion in the C9ORF72 gene.
    Title: Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism.
  10. serum exosomal hnRNPH1 mRNA levels in hepatocellular carcinoma (HCC) patients were remarkably higher than in the other groups; exosomal hnRNPH1 mRNA levels in HCC patients were associated with the Child-Pugh classification, portal vein tumor emboli, lymph node metastasis, TNM stage and overall survival; findings suggested that serum exosomal hnRNPH1 mRNA could be an effective marker for HCC in high HBV prevalence areas
    Title: Serum exosomal hnRNPH1 mRNA as a novel marker for hepatocellular carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Neurodevelopmental disorder with craniofacial dysmorphism and skeletal defects
MedGen: C5774235 OMIM: 620083 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPH1 is increased by RRE PubMed
Vif vif Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G13-2: AGGGA) to regulate the levels of vif and vpr mRNA, and the amounts of Vif and Vpr protein expression PubMed
vif Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G12-1: AGGGA) to regulate the levels of vif mRNA and Vif protein expression PubMed
Vpr vpr Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G13-2: AGGGA) to regulate the levels of vif and vpr mRNA, and the amounts of Vif and Vpr protein expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686A15170

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables poly(U) RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing TAS
Traceable Author Statement
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein H
Names
epididymis secretory sperm binding protein
heterogeneous nuclear ribonucleoprotein H1 (H)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257293.2 → NP_001244222.1  heterogeneous nuclear ribonucleoprotein H isoform a

    See identical proteins and their annotated locations for NP_001244222.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2, 12-18, and 40 all encode the same isoform (a).
    Source sequence(s)
    BC001348, BQ028714, DA204744
    Consensus CDS
    CCDS4446.1
    UniProtKB/Swiss-Prot
    B3KW86, D3DWQ2, P31943, Q6IBM4
    UniProtKB/TrEMBL
    A0A384MEJ3, B4DFK9
    Related
    ENSP00000377082.4, ENST00000393432.9
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  2. NM_001363572.2 → NP_001350501.1  heterogeneous nuclear ribonucleoprotein H isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice junction, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 24, and 46 all encode the same isoform (b).
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS87357.1
    UniProtKB/TrEMBL
    E9PCY7
    Related
    ENSP00000426275.1, ENST00000510411.6
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  3. NM_001364225.2 → NP_001351154.1  heterogeneous nuclear ribonucleoprotein H isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 5-8, encodes the longest isoform (c).
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS93836.1
    UniProtKB/TrEMBL
    B4DFK9, G8JLB6
    Conserved Domains (4) summary
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:93 → 188
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_001364226.2 → NP_001351155.1  heterogeneous nuclear ribonucleoprotein H isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6-8, encodes isoform c.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS93836.1
    UniProtKB/TrEMBL
    B4DFK9, G8JLB6
    Conserved Domains (4) summary
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:93 → 188
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. NM_001364227.2 → NP_001351156.1  heterogeneous nuclear ribonucleoprotein H isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 4, 5, 7, and 8, encodes isoform c.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS93836.1
    UniProtKB/TrEMBL
    B4DFK9, G8JLB6
    Conserved Domains (4) summary
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:93 → 188
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. NM_001364228.2 → NP_001351157.1  heterogeneous nuclear ribonucleoprotein H isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 4-6 and 8, encodes isoform c.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS93836.1
    UniProtKB/TrEMBL
    B4DFK9, G8JLB6
    Conserved Domains (4) summary
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:93 → 188
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. NM_001364229.2 → NP_001351158.1  heterogeneous nuclear ribonucleoprotein H isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 4-7, encodes isoform c.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS93836.1
    UniProtKB/TrEMBL
    B4DFK9, G8JLB6
    Related
    ENSP00000327539.6, ENST00000329433.11
    Conserved Domains (4) summary
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:93 → 188
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. NM_001364230.2 → NP_001351159.1  heterogeneous nuclear ribonucleoprotein H isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 11, encodes isoform d.
    Source sequence(s)
    AC136604
    Conserved Domains (4) summary
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:93 → 188
    RRM_SF; RNA recognition motif (RRM) superfamily

  9. NM_001364231.2 → NP_001351160.1  heterogeneous nuclear ribonucleoprotein H isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 34, encodes isoform l.
    Source sequence(s)
    AC136604
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  10. NM_001364232.2 → NP_001351161.1  heterogeneous nuclear ribonucleoprotein H isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 9, encodes isoform d.
    Source sequence(s)
    AC136604
    Conserved Domains (4) summary
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:93 → 188
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. NM_001364233.2 → NP_001351162.1  heterogeneous nuclear ribonucleoprotein H isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 1, 2, 13-18, and 40, encodes isoform a.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS4446.1
    UniProtKB/Swiss-Prot
    B3KW86, D3DWQ2, P31943, Q6IBM4
    UniProtKB/TrEMBL
    A0A384MEJ3, B4DFK9
    Related
    ENSP00000429661.2, ENST00000521116.6
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  12. NM_001364234.2 → NP_001351163.1  heterogeneous nuclear ribonucleoprotein H isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1, 2, 12, 14-18, and 40, encodes isoform a.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS4446.1
    UniProtKB/Swiss-Prot
    B3KW86, D3DWQ2, P31943, Q6IBM4
    UniProtKB/TrEMBL
    A0A384MEJ3, B4DFK9
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  13. NM_001364235.2 → NP_001351164.1  heterogeneous nuclear ribonucleoprotein H isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 1, 2, 12, 13, 15-18, and 40, encodes isoform a.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS4446.1
    UniProtKB/Swiss-Prot
    B3KW86, D3DWQ2, P31943, Q6IBM4
    UniProtKB/TrEMBL
    A0A384MEJ3, B4DFK9
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  14. NM_001364236.2 → NP_001351165.1  heterogeneous nuclear ribonucleoprotein H isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 1, 2, 12-14, 16-18, and 40, encodes isoform a.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS4446.1
    UniProtKB/Swiss-Prot
    B3KW86, D3DWQ2, P31943, Q6IBM4
    UniProtKB/TrEMBL
    A0A384MEJ3, B4DFK9
    Related
    ENSP00000426518.2, ENST00000513225.6
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  15. NM_001364237.2 → NP_001351166.1  heterogeneous nuclear ribonucleoprotein H isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 1, 2, 12-15, 17, 18, and 40, encodes isoform a.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS4446.1
    UniProtKB/Swiss-Prot
    B3KW86, D3DWQ2, P31943, Q6IBM4
    UniProtKB/TrEMBL
    A0A384MEJ3, B4DFK9
    Related
    ENSP00000425343.2, ENST00000515714.6
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  16. NM_001364238.2 → NP_001351167.1  heterogeneous nuclear ribonucleoprotein H isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 1, 2, 12-16, 18, and 40, encodes isoform a.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS4446.1
    UniProtKB/Swiss-Prot
    B3KW86, D3DWQ2, P31943, Q6IBM4
    UniProtKB/TrEMBL
    A0A384MEJ3, B4DFK9
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  17. NM_001364239.2 → NP_001351168.1  heterogeneous nuclear ribonucleoprotein H isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 1, 2, 12-17, and 40, encodes isoform a.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS4446.1
    UniProtKB/Swiss-Prot
    B3KW86, D3DWQ2, P31943, Q6IBM4
    UniProtKB/TrEMBL
    A0A384MEJ3, B4DFK9
    Related
    ENSP00000421695.2, ENST00000515158.6
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  18. NM_001364240.2 → NP_001351169.1  heterogeneous nuclear ribonucleoprotein H isoform e

    Status: REVIEWED

    Source sequence(s)
    AC136604
    UniProtKB/TrEMBL
    A0A9L9PY23
    Related
    ENSP00000516644.1, ENST00000706924.1
    Conserved Domains (4) summary
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:93 → 188
    RRM_SF; RNA recognition motif (RRM) superfamily

  19. NM_001364241.2 → NP_001351170.1  heterogeneous nuclear ribonucleoprotein H isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 21, 22, and 43, encodes isoform f.
    Source sequence(s)
    AC136604
    UniProtKB/TrEMBL
    B4DFK9
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  20. NM_001364242.2 → NP_001351171.1  heterogeneous nuclear ribonucleoprotein H isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 20, 22, and 43, encodes isoform f.
    Source sequence(s)
    AC136604
    UniProtKB/TrEMBL
    B4DFK9
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  21. NM_001364243.2 → NP_001351172.1  heterogeneous nuclear ribonucleoprotein H isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 20, 21, and 43, encodes isoform f.
    Source sequence(s)
    AC136604
    UniProtKB/TrEMBL
    B4DFK9
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  22. NM_001364244.2 → NP_001351173.1  heterogeneous nuclear ribonucleoprotein H isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variant 44, encodes isoform g.
    Source sequence(s)
    AC136604
    UniProtKB/TrEMBL
    B4DFK9
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  23. NM_001364245.2 → NP_001351174.1  heterogeneous nuclear ribonucleoprotein H isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 3 and 46, encodes isoform b.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS87357.1
    UniProtKB/TrEMBL
    E9PCY7
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  24. NM_001364246.2 → NP_001351175.1  heterogeneous nuclear ribonucleoprotein H isoform t

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variant 26, encodes isoform t.
    Source sequence(s)
    AC136604
    UniProtKB/TrEMBL
    H0YBD7
    Related
    ENSP00000429270.2, ENST00000523921.2
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  25. NM_001364247.2 → NP_001351176.1  heterogeneous nuclear ribonucleoprotein H isoform t

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variant 25, encodes isoform t.
    Source sequence(s)
    AC136604
    UniProtKB/TrEMBL
    H0YBD7
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  26. NM_001364248.2 → NP_001351177.1  heterogeneous nuclear ribonucleoprotein H isoform h

    Status: REVIEWED

    Source sequence(s)
    AC136604
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  27. NM_001364250.2 → NP_001351179.1  heterogeneous nuclear ribonucleoprotein H isoform i

    Status: REVIEWED

    Source sequence(s)
    AC136604
    Conserved Domains (3) summary
    cd12734
    Location:237 → 312
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:203 → 238
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:41 → 136
    RRM_SF; RNA recognition motif (RRM) superfamily

  28. NM_001364251.2 → NP_001351180.1  heterogeneous nuclear ribonucleoprotein H isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variants 30 and 31, encodes isoform j.
    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger

  29. NM_001364252.2 → NP_001351181.1  heterogeneous nuclear ribonucleoprotein H isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 29 and 31, encodes isoform j.
    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger

  30. NM_001364253.2 → NP_001351182.1  heterogeneous nuclear ribonucleoprotein H isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variants 29 and 30, encodes isoform j.
    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger

  31. NM_001364254.2 → NP_001351183.1  heterogeneous nuclear ribonucleoprotein H isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variants 33 and 51, encodes isoform k.
    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  32. NM_001364255.2 → NP_001351184.1  heterogeneous nuclear ribonucleoprotein H isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (33), as well as variants 32 and 51, encodes isoform k.
    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  33. NM_001395176.1 → NP_001382105.1  heterogeneous nuclear ribonucleoprotein H isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (34), as well as variant 10, encodes isoform l.
    Source sequence(s)
    AC136604
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  34. NM_001395177.1 → NP_001382106.1  heterogeneous nuclear ribonucleoprotein H isoform m

    Status: REVIEWED

    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:289 → 363
    RRM_SF; RNA recognition motif (RRM) superfamily

  35. NM_001395178.1 → NP_001382107.1  heterogeneous nuclear ribonucleoprotein H isoform n

    Status: REVIEWED

    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:289 → 363
    RRM_SF; RNA recognition motif (RRM) superfamily

  36. NM_001395179.1 → NP_001382108.1  heterogeneous nuclear ribonucleoprotein H isoform o

    Status: REVIEWED

    Description
    Transcript Variant: This variant (37), as well as variant 38, encodes isoform o.
    Source sequence(s)
    AC136604
    UniProtKB/TrEMBL
    B4DFK9
    Conserved Domains (2) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:282 → 356
    RRM_SF; RNA recognition motif (RRM) superfamily

  37. NM_001395180.1 → NP_001382109.1  heterogeneous nuclear ribonucleoprotein H isoform o

    Status: REVIEWED

    Description
    Transcript Variant: This variant (38), as well as variant 37, encodes isoform o.
    Source sequence(s)
    AC136604
    UniProtKB/TrEMBL
    B4DFK9
    Conserved Domains (2) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:282 → 356
    RRM_SF; RNA recognition motif (RRM) superfamily

  38. NM_001395181.1 → NP_001382110.1  heterogeneous nuclear ribonucleoprotein H isoform p

    Status: REVIEWED

    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:289 → 363
    RRM_SF; RNA recognition motif (RRM) superfamily

  39. NM_001395182.1 → NP_001382111.1  heterogeneous nuclear ribonucleoprotein H isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (40), as well as variants 1, 2, and 12-18, encodes isoform a.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS4446.1
    UniProtKB/Swiss-Prot
    B3KW86, D3DWQ2, P31943, Q6IBM4
    UniProtKB/TrEMBL
    A0A384MEJ3, B4DFK9
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  40. NM_001395183.1 → NP_001382112.1  heterogeneous nuclear ribonucleoprotein H isoform q

    Status: REVIEWED

    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:289 → 363
    RRM_SF; RNA recognition motif (RRM) superfamily

  41. NM_001395184.1 → NP_001382113.1  heterogeneous nuclear ribonucleoprotein H isoform r

    Status: REVIEWED

    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:289 → 363
    RRM_SF; RNA recognition motif (RRM) superfamily

  42. NM_001395186.1 → NP_001382115.1  heterogeneous nuclear ribonucleoprotein H isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (43), as well as variants 20-22, encodes isoform f.
    Source sequence(s)
    AC136604
    UniProtKB/TrEMBL
    B4DFK9
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:282 → 357
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  43. NM_001395187.1 → NP_001382116.1  heterogeneous nuclear ribonucleoprotein H isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (44), as well as variant 23, encodes isoform g.
    Source sequence(s)
    AC136604
    UniProtKB/TrEMBL
    B4DFK9
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  44. NM_001395188.1 → NP_001382117.1  heterogeneous nuclear ribonucleoprotein H isoform s

    Status: REVIEWED

    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    pfam08080
    Location:255 → 283
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:282 → 356
    RRM_SF; RNA recognition motif (RRM) superfamily

  45. NM_001395189.1 → NP_001382118.1  heterogeneous nuclear ribonucleoprotein H isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (46), as well as variants 3 and 24, encodes isoform b.
    Source sequence(s)
    AC136604
    Consensus CDS
    CCDS87357.1
    UniProtKB/TrEMBL
    E9PCY7
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  46. NM_001395190.1 → NP_001382119.1  heterogeneous nuclear ribonucleoprotein H isoform u

    Status: REVIEWED

    Source sequence(s)
    AC136604
    UniProtKB/TrEMBL
    B4DFK9
    Conserved Domains (3) summary
    pfam08080
    Location:178 → 213
    zf-RNPHF; RNPHF zinc finger
    cd12731
    Location:26 → 115
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:212 → 287
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  47. NM_001395191.1 → NP_001382120.1  heterogeneous nuclear ribonucleoprotein H isoform v

    Status: REVIEWED

    Source sequence(s)
    AC136604
    Conserved Domains (3) summary
    smart00360
    Location:113 → 149
    RRM; RNA recognition motif
    pfam08080
    Location:149 → 184
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:183 → 257
    RRM_SF; RNA recognition motif (RRM) superfamily

  48. NM_001395192.1 → NP_001382121.1  heterogeneous nuclear ribonucleoprotein H isoform w

    Status: REVIEWED

    Source sequence(s)
    AC136604
    Conserved Domains (3) summary
    smart00360
    Location:113 → 149
    RRM; RNA recognition motif
    pfam08080
    Location:149 → 184
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:183 → 257
    RRM_SF; RNA recognition motif (RRM) superfamily

  49. NM_001395193.1 → NP_001382122.1  heterogeneous nuclear ribonucleoprotein H isoform x

    Status: REVIEWED

    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    pfam08080
    Location:130 → 153
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:152 → 226
    RRM_SF; RNA recognition motif (RRM) superfamily

  50. NM_001395194.1 → NP_001382123.1  heterogeneous nuclear ribonucleoprotein H isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (51), as well as variants 32 and 33, encodes isoform k.
    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger
    cd12734
    Location:88 → 163
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

  51. NM_001395195.1 → NP_001382124.1  heterogeneous nuclear ribonucleoprotein H isoform y

    Status: REVIEWED

    Source sequence(s)
    AC136604
    Conserved Domains (2) summary
    pfam08080
    Location:54 → 89
    zf-RNPHF; RNPHF zinc finger
    cl17169
    Location:88 → 162
    RRM_SF; RNA recognition motif (RRM) superfamily

  52. NM_005520.3 → NP_005511.1  heterogeneous nuclear ribonucleoprotein H isoform a

    See identical proteins and their annotated locations for NP_005511.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 12-18, and 40 all encode the same isoform (a).
    Source sequence(s)
    AK124530, BC001348, DA603645
    Consensus CDS
    CCDS4446.1
    UniProtKB/Swiss-Prot
    B3KW86, D3DWQ2, P31943, Q6IBM4
    UniProtKB/TrEMBL
    A0A384MEJ3, B4DFK9
    Related
    ENSP00000397797.2, ENST00000442819.6
    Conserved Domains (4) summary
    pfam08080
    Location:255 → 290
    zf-RNPHF; RNPHF zinc finger
    cd12729
    Location:10 → 88
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103 → 192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
    cd12734
    Location:289 → 364
    RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    179614178..179634784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_016107298.1 Reference GRCh38.p14 PATCHES

    Range
    380457..401011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    180168628..180189994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31943.4 GenPept UniProtKB/Swiss-Prot:P31943

Gene LinkOut

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