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Uros1 Uroporphyrinogen III synthase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31817, updated on 26-Apr-2024

Summary

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Official Symbol
Uros1provided by FlyBase
Official Full Name
Uroporphyrinogen III synthase 1provided by FlyBase
Primary source
FLYBASE:FBgn0030066
Locus tag
Dmel_CG1885
See related
AllianceGenome:FB:FBgn0030066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1885; Dmel\CG1885
Summary
Predicted to enable uroporphyrinogen-III synthase activity. Predicted to be involved in heme biosynthetic process and uroporphyrinogen III biosynthetic process. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
8B6-8B6; 1-25 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8898554..8900264, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8792587..8794297, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Moesin Neighboring gene RNA-binding motif protein 13 Neighboring gene enhancer of rudimentary

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Joint estimates of quantitative trait locus effect and frequency using synthetic recombinant populations of Drosophila melanogaster. Macdonald SJ, et al. Genetics, 2007 Jun. PMID 17435224, Free PMC Article
  2. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article
  3. Genomic organization of gypsy chromatin insulators in Drosophila melanogaster. Ramos E, et al. Genetics, 2006 Apr. PMID 16452134, Free PMC Article
  4. The soluble proteome of the Drosophila antenna. Anholt RR, et al. Chem Senses, 2010 Jan. PMID 19917591, Free PMC Article
  5. Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila. Feng S, et al. Chem Biol, 2015 Nov 19. PMID 26526100

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables uroporphyrinogen-III synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uroporphyrinogen-III synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables uroporphyrinogen-III synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in tetrapyrrole biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in uroporphyrinogen III biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in uroporphyrinogen III biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in uroporphyrinogen III biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uroporphyrinogen III synthase 1
Names
CG1885-PA
CG1885-PB
Uros1-PA
Uros1-PB
NP_001259362.1
NP_572507.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    8898554..8900264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272433.1 → NP_001259362.1  uroporphyrinogen III synthase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259362.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9YK67, Q9W3B3
    Conserved Domains (1) summary
    pfam02602
    Location:20 → 251
    HEM4; Uroporphyrinogen-III synthase HemD

  2. NM_132279.4 → NP_572507.1  uroporphyrinogen III synthase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572507.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A9YK67, Q9W3B3
    Related
    FBpp0071211
    Conserved Domains (1) summary
    pfam02602
    Location:20 → 251
    HEM4; Uroporphyrinogen-III synthase HemD
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W3B3 Q9W3B3

Gene LinkOut

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