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ITPR1 inositol 1,4,5-trisphosphate receptor type 1 [ Bos taurus (cattle) ]

Gene ID: 317697, updated on 11-Apr-2024

Summary

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Official Symbol
ITPR1provided by VGNC
Official Full Name
inositol 1,4,5-trisphosphate receptor type 1provided by VGNC
Primary source
VGNC:VGNC:30346
See related
Ensembl:ENSBTAG00000020455
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
60
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (21522784..21876681, complement)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101907920 Neighboring gene basic helix-loop-helix family member e40 Neighboring gene uncharacterized LOC132343490 Neighboring gene microRNA mir-2285am Neighboring gene U6 spliceosomal RNA Neighboring gene sulfatase modifying factor 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of redox potential and Ca2+ on the inositol 1,4,5-trisphosphate receptor L3-1 loop region: implications for receptor regulation. Kang S, et al. J Biol Chem, 2008 Sep 12. PMID 18635540
  2. Structure of the type 1 inositol 1,4,5-trisphosphate receptor revealed by electron cryomicroscopy. Serysheva II, et al. J Biol Chem, 2003 Jun 13. PMID 12714606
  3. Smooth muscle and brain inositol 1,4,5-trisphosphate receptors are structurally and functionally similar. Marks AR, et al. J Biol Chem, 1990 Dec 5. PMID 2174422
  4. STIM1 positively regulates the Ca2+ release activity of the inositol 1,4,5-trisphosphate receptor in bovine aortic endothelial cells. Béliveau É, et al. PLoS One, 2014. PMID 25506690, Free PMC Article
  5. Global dynamic conformational changes in the suppressor domain of IP3 receptor by stepwise binding of the two lobes of calmodulin. Kang S, et al. FASEB J, 2011 Mar. PMID 21084695

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STIM1 and STIM2 are expressed in bovine aortic endothelial cells and they both interact with IP3R-1.
    Title: STIM1 positively regulates the Ca2+ release activity of the inositol 1,4,5-trisphosphate receptor in bovine aortic endothelial cells.
  2. we propose a model in which the partial unfolding of the suppressor domain by apo-CaM and the stepwise binding of the N lobe of CaM to the suppressor domain are important elements of calcium/CaM inhibition of IP(3)R
    Title: Global dynamic conformational changes in the suppressor domain of IP3 receptor by stepwise binding of the two lobes of calmodulin.
  3. the redox potential and Ca(2+) can regulate IP(3)R through totally different mechanisms: Ca(2+) by the indirect effect and the redox potential by direct action causing conformational changes
    Title: Effects of redox potential and Ca2+ on the inositol 1,4,5-trisphosphate receptor L3-1 loop region: implications for receptor regulation.
  4. the InsP3R/Ca2+ channel is regulated by chromogranin B
    Title: A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel.
  5. structural mapping of the amino acid sequences to several functional domains is deduced within the structure of the InsP3R1 tetramer
    Title: Structure of the type 1 inositol 1,4,5-trisphosphate receptor revealed by electron cryomicroscopy.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables inositol 1,4,5 trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
inositol 1,4,5-trisphosphate receptor type 1
Names
IP3 receptor
IP3R 1
inositol 1,4,5-triphosphate receptor, type 1
insP3R1
type 1 InsP3 receptor
type 1 inositol 1,4,5-trisphosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174841.2 → NP_777266.1  inositol 1,4,5-trisphosphate receptor type 1

    See identical proteins and their annotated locations for NP_777266.1

    Status: PROVISIONAL

    Source sequence(s)
    AF157625
    UniProtKB/Swiss-Prot
    Q7M2U0, Q9TU34
    UniProtKB/TrEMBL
    F1MX21
    Related
    ENSBTAP00000047903.4, ENSBTAT00000054653.4
    Conserved Domains (6) summary
    smart00472
    Location:231 → 287
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    pfam00520
    Location:2301 → 2560
    Ion_trans; Ion transport protein
    pfam01365
    Location:476 → 665
    RYDR_ITPR; RIH domain
    pfam02815
    Location:232 → 433
    MIR; MIR domain
    pfam08454
    Location:1924 → 2029
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:4 → 225
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    21522784..21876681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TU34.1 GenPept UniProtKB/Swiss-Prot:Q9TU34

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous