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Fzd5 frizzled class receptor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317674, updated on 4-Jan-2025

Summary

Official Symbol
Fzd5provided by RGD
Official Full Name
frizzled class receptor 5provided by RGD
Primary source
RGD:631406
See related
EnsemblRapid:ENSRNOG00000014678 AllianceGenome:RGD:631406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables Wnt-protein binding activity. Involved in presynapse assembly. Is active in glutamatergic synapse. Orthologous to human FZD5 (frizzled class receptor 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Fzd5 in Genome Data Viewer
Location:
9q32
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (73606860..73614039, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (66113096..66120276, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (71443784..71445541, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094695 Neighboring gene uncharacterized LOC134480380 Neighboring gene cyclin Y-like 1 Neighboring gene basic proline-rich protein-like Neighboring gene pleckstrin homology domain containing M3 Neighboring gene uncharacterized LOC120094696 Neighboring gene crystallin, gamma E

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity  
enables Wnt receptor activity  
enables Wnt receptor activity  
enables Wnt receptor activity  
enables Wnt receptor activity  
enables Wnt-protein binding  
enables Wnt-protein binding  
enables Wnt-protein binding PubMed 
enables Wnt-protein binding  
enables amyloid-beta binding  
enables amyloid-beta binding  
enables lipid binding  
enables protein kinase binding  
enables protein kinase binding  
enables protein-containing complex binding  
enables protein-containing complex binding  
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
Items 1 - 25 of 68
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway  
involved_in Spemann organizer formation  
involved_in Spemann organizer formation  
involved_in T cell differentiation in thymus  
acts_upstream_of_or_within T cell differentiation in thymus  
acts_upstream_of_or_within Wnt signaling pathway  
involved_in angiogenesis  
acts_upstream_of_or_within angiogenesis  
involved_in anterior/posterior axis specification, embryo  
involved_in anterior/posterior axis specification, embryo  
involved_in apoptotic process involved in morphogenesis  
acts_upstream_of_or_within apoptotic process involved in morphogenesis  
involved_in biological_process  
involved_in branching involved in labyrinthine layer morphogenesis  
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis  
involved_in canonical Wnt signaling pathway  
involved_in canonical Wnt signaling pathway  
involved_in canonical Wnt signaling pathway  
involved_in canonical Wnt signaling pathway  
involved_in cellular response to molecule of bacterial origin  
involved_in cellular response to molecule of bacterial origin  
involved_in chorionic trophoblast cell differentiation  
acts_upstream_of_or_within chorionic trophoblast cell differentiation  
involved_in embryonic axis specification  
acts_upstream_of_or_within embryonic camera-type eye development  
involved_in embryonic camera-type eye morphogenesis  
involved_in embryonic camera-type eye morphogenesis  
involved_in eye development  
involved_in eye development  
involved_in glandular epithelial cell maturation  
acts_upstream_of_or_within glandular epithelial cell maturation  
involved_in intestinal epithelial cell maturation  
acts_upstream_of_or_within intestinal epithelial cell maturation  
involved_in labyrinthine layer blood vessel development  
acts_upstream_of_or_within labyrinthine layer blood vessel development  
involved_in negative regulation of cell population proliferation  
acts_upstream_of_or_within negative regulation of cell population proliferation  
involved_in non-canonical Wnt signaling pathway  
involved_in non-canonical Wnt signaling pathway  
involved_in non-canonical Wnt signaling pathway  
involved_in non-canonical Wnt signaling pathway  
acts_upstream_of_or_within positive regulation of JUN kinase activity  
involved_in positive regulation of T cell cytokine production  
involved_in positive regulation of T cell cytokine production  
involved_in positive regulation of interleukin-1 beta production  
involved_in positive regulation of interleukin-1 beta production  
involved_in positive regulation of protein targeting to mitochondrion PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of tumor necrosis factor production  
involved_in positive regulation of tumor necrosis factor production  
involved_in positive regulation of type II interferon production  
involved_in positive regulation of type II interferon production  
involved_in post-embryonic camera-type eye development  
acts_upstream_of_or_within post-embryonic camera-type eye development  
involved_in post-embryonic camera-type eye development  
involved_in presynapse assembly PubMed 
involved_in presynapse assembly PubMed 
involved_in presynapse assembly PubMed 
involved_in regulation of bicellular tight junction assembly  
acts_upstream_of_or_within regulation of bicellular tight junction assembly  
involved_in regulation of chorionic trophoblast cell proliferation  
acts_upstream_of_or_within regulation of chorionic trophoblast cell proliferation  
involved_in regulation of mitophagy PubMed 
involved_in syncytiotrophoblast cell differentiation involved in labyrinthine layer development  
acts_upstream_of_or_within syncytiotrophoblast cell differentiation involved in labyrinthine layer development  
acts_upstream_of_or_within vasculature development  
Items 1 - 25 of 68
Items 1 - 20 of 22
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi apparatus  
located_in Golgi membrane  
located_in axon  
located_in bicellular tight junction  
located_in bicellular tight junction  
located_in cell surface  
located_in cell surface  
located_in dendrite  
located_in early endosome  
located_in early endosome  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in perikaryon  
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
is_active_in synapse PubMed 
Items 1 - 20 of 22

General protein information

Preferred Names
frizzled-5
Names
frizzled family receptor 5
fz-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173838.3 → NP_776210.2  frizzled-5 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q8CHL0
    UniProtKB/TrEMBL
    A0A0G2JXX8, A6IPI5
    Related
    ENSRNOP00000099774.1, ENSRNOT00000154504.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    73606860..73614039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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