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Eif1a eukaryotic translation initiation factor 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 317163, updated on 13-Apr-2024

Summary

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Official Symbol
Eif1aprovided by RGD
Official Full Name
eukaryotic translation initiation factor 1Aprovided by RGD
Primary source
RGD:1306331
See related
Ensembl:ENSRNOG00000031421 AllianceGenome:RGD:1306331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables ribosomal large subunit binding activity. Predicted to be involved in translational initiation. Predicted to be active in cytoplasm. Orthologous to human EIF1AY (eukaryotic translation initiation factor 1A Y-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 208.2), Spleen (RPKM 180.5) and 9 other tissues See more
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Genomic context

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Location:
18q11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (41512298..41524645)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (39325695..39338043)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (40586315..40598661)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene TIR domain containing adaptor molecule 2 Neighboring gene transmembrane p24 trafficking protein 7 Neighboring gene 40S ribosomal protein S23-like Neighboring gene cysteine dioxygenase type 1 Neighboring gene autophagy related 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Topography of ribosomes and initiation complexes from rat liver as revealed by atomic force microscopy. Wu X, et al. Biol Chem, 1997 May. PMID 9191023
  2. Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes. Andreev DE, et al. Genome Biol, 2015 May 6. PMID 25943107, Free PMC Article
  3. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG. Annu Rev Biochem, 2014. PMID 24499181
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal large subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 1A
Names
Ab1-287
X-linked eukaryotic translation initiation factor 1A
eIF-1A
eIF-4C
eukaryotic translation initiation factor 4C
liver regeneration-related protein LRRG048

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008773.3 → NP_001008773.3  eukaryotic translation initiation factor 1A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q6VV72
    UniProtKB/TrEMBL
    A6IWW1, Q566D5
    Related
    ENSRNOP00000092892.1, ENSRNOT00000099676.1
    Conserved Domains (1) summary
    PTZ00329
    Location:1 → 131
    PTZ00329; eukaryotic translation initiation factor 1A; Provisional

  2. NM_001394990.1 → NP_001381919.1  eukaryotic translation initiation factor 1A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q6VV72
    UniProtKB/TrEMBL
    A6IWW1, Q566D5
    Related
    ENSRNOP00000094920.1, ENSRNOT00000099432.1
    Conserved Domains (1) summary
    PTZ00329
    Location:1 → 131
    PTZ00329; eukaryotic translation initiation factor 1A; Provisional

  3. NM_001394991.1 → NP_001381920.1  eukaryotic translation initiation factor 1A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q6VV72
    UniProtKB/TrEMBL
    A6IWW1, Q566D5
    Related
    ENSRNOP00000046345.3, ENSRNOT00000041237.6
    Conserved Domains (1) summary
    PTZ00329
    Location:1 → 131
    PTZ00329; eukaryotic translation initiation factor 1A; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    41512298..41524645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6VV72.3 GenPept UniProtKB/Swiss-Prot:Q6VV72

Gene LinkOut

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