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Myom1 myomesin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316740, updated on 13-Apr-2024

Summary

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Official Symbol
Myom1provided by RGD
Official Full Name
myomesin 1provided by RGD
Primary source
RGD:631436
See related
Ensembl:ENSRNOG00000057701 AllianceGenome:RGD:631436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity; kinase binding activity; and protein homodimerization activity. Involved in extraocular skeletal muscle development. Located in M band. Orthologous to human MYOM1 (myomesin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 1896.5) and Heart (RPKM 1389.6) See more
Orthologs
human mouse all
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Genomic context

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Location:
9q38
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (118362547..118485954)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (110916156..111039344)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (119353840..119469196)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene myosin light chain 12B Neighboring gene uncharacterized LOC102555687 Neighboring gene myosin light chain 12A Neighboring gene uncharacterized LOC102555849 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Superhelical architecture of the myosin filament-linking protein myomesin with unusual elastic properties. Pinotsis N, et al. PLoS Biol, 2012 Feb. PMID 22347812, Free PMC Article
  2. Nuclear localization of Myomesin-1: possible functions. Reddy KB, et al. J Muscle Res Cell Motil, 2008. PMID 18521710
  3. Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. Pinotsis N, et al. EMBO J, 2008 Jan 9. PMID 18059477, Free PMC Article
  4. Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle. Porter JD, et al. J Exp Biol, 2003 Sep. PMID 12878677
  5. Induction of insulin-like growth factor 1 splice forms by subfragments of myofibrillar proteins. Kravchenko IV, et al. Mol Cell Endocrinol, 2015 Jan 5. PMID 25152160

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in extraocular skeletal muscle development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in M band ISO
Inferred from Sequence Orthology
more info
  
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myomesin-1
Names
myomesin 1 (skelemin) 185kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191584.1 → NP_001178513.1  myomesin-1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K5P5, A0A8I6GBP8
    Conserved Domains (4) summary
    cd00063
    Location:641 → 734
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:1576 → 1579
    Ig; Ig strand A [structural motif]
    cd20951
    Location:281 → 374
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1576 → 1667
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    118362547..118485954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083797.2 → XP_038939725.1  myomesin-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5P5, A0A8I6GFM8
    Related
    ENSRNOP00000087945.1
    Conserved Domains (4) summary
    cd00063
    Location:641 → 734
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:1479 → 1482
    Ig; Ig strand A [structural motif]
    cd20951
    Location:281 → 374
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1479 → 1570
    Ig; Immunoglobulin domain

  2. XM_039083799.2 → XP_038939727.1  myomesin-1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K5P5, A0A8I6GBP8
    Related
    ENSRNOP00000085118.1
    Conserved Domains (4) summary
    cd00063
    Location:641 → 734
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:1576 → 1579
    Ig; Ig strand A [structural motif]
    cd20951
    Location:281 → 374
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1576 → 1667
    Ig; Immunoglobulin domain

  3. XM_039083798.2 → XP_038939726.1  myomesin-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5P5, A0A8I6GFM8
    Conserved Domains (4) summary
    cd00063
    Location:641 → 734
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:1479 → 1482
    Ig; Ig strand A [structural motif]
    cd20951
    Location:281 → 374
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1479 → 1570
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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