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Lpin2 lipin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316737, updated on 5-Mar-2024

Summary

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Official Symbol
Lpin2provided by RGD
Official Full Name
lipin 2provided by RGD
Primary source
RGD:1304588
See related
Ensembl:ENSRNOG00000014876 AllianceGenome:RGD:1304588
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; fatty acid catabolic process; and triglyceride biosynthetic process. Predicted to be active in cytosol; endoplasmic reticulum membrane; and nucleus. Orthologous to human LPIN2 (lipin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 124.7), Spleen (RPKM 111.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lpin2 in Genome Data Viewer
Location:
9q38
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (118529988..118604796)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (111083378..111158193)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (119517101..119591533)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555849 Neighboring gene U6 spliceosomal RNA Neighboring gene tRNA splicing endonuclease subunit 2, pseudogene 1 Neighboring gene U7 small nuclear RNA Neighboring gene elastin microfibril interfacer 2 Neighboring gene structural maintenance of chromosomes flexible hinge domain containing 1 Neighboring gene Y box binding protein 1, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver. Kok BPC, et al. J Lipid Res, 2013 Jun. PMID 23505321, Free PMC Article
  2. A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. Donkor J, et al. J Biol Chem, 2009 Oct 23. PMID 19717560, Free PMC Article
  3. Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. Donkor J, et al. J Biol Chem, 2007 Feb 9. PMID 17158099
  4. Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2. Grimsey N, et al. J Biol Chem, 2008 Oct 24. PMID 18694939, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidate phosphatase LPIN2
NP_001101706.1
XP_006245724.1
XP_006245725.1
XP_006245726.1
XP_006245727.1
XP_038939723.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108236.1 → NP_001101706.1  phosphatidate phosphatase LPIN2

    See identical proteins and their annotated locations for NP_001101706.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474043
    UniProtKB/TrEMBL
    A0A8I5ZKH7, A6KF98, D3ZYB4
    Related
    ENSRNOP00000020476.5, ENSRNOT00000020476.8
    Conserved Domains (5) summary
    PHA03247
    Location:326 → 483
    PHA03247; large tegument protein UL36; Provisional
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:635 → 860
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam15017
    Location:873 → 891
    WRNPLPNID; Putative WW-binding domain and destruction box
    pfam16876
    Location:467 → 558
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    118529988..118604796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083795.1 → XP_038939723.1  phosphatidate phosphatase LPIN2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZKH7, A6KF98, D3ZYB4
    Conserved Domains (5) summary
    PHA03247
    Location:326 → 483
    PHA03247; large tegument protein UL36; Provisional
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:635 → 860
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam15017
    Location:873 → 891
    WRNPLPNID; Putative WW-binding domain and destruction box
    pfam16876
    Location:467 → 558
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  2. XM_006245662.5 → XP_006245724.1  phosphatidate phosphatase LPIN2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JY62, A0A8I5ZKH7
    Related
    ENSRNOP00000070532.1
    Conserved Domains (4) summary
    pfam15017
    Location:912 → 932
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:39 → 144
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:673 → 898
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:505 → 595
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  3. XM_006245665.5 → XP_006245727.1  phosphatidate phosphatase LPIN2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AH46
    Conserved Domains (4) summary
    pfam15017
    Location:861 → 881
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:39 → 144
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:673 → 847
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:505 → 595
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  4. XM_006245663.5 → XP_006245725.1  phosphatidate phosphatase LPIN2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZKH7
    Conserved Domains (4) summary
    pfam15017
    Location:911 → 931
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:39 → 144
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:672 → 897
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:504 → 594
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  5. XM_006245664.5 → XP_006245726.1  phosphatidate phosphatase LPIN2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZKH7
    Conserved Domains (4) summary
    pfam15017
    Location:882 → 902
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:9 → 114
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:643 → 868
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:475 → 565
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
Nucleotide Protein Strain
Heading Accession and Version

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